CAS 118-74-1 MFCD00000540-Hexachlorobenzene 六氯苯 TAO{mole}

Hexachlorobenzene 六氯苯

CAS 118-74-1 MFCD00000540

化学结构图

SMILES: ClC1C(Cl)C(Cl)C(Cl)C(Cl)C1Cl

化学属性

Mol. Formula	C₆Cl₆
Mol. Weight	284.78
Boiling Point
Melting Point	228-229ºC
Flash Point	-
Solubility	不溶于水，溶于乙醚、氯仿等多数有机溶剂。
Density	1.5691
Stability	对光敏感

别名和识别编码

Chemical Name	Hexachlorobenzene
Synonym	'LGC' (1131) 1,2,3,4,5,6-HEXACHLOROBENZENE ANTICARIE(R) Anticarie Antitcatil BUNT-CURE(R) BUNT-NO-MORE(R) Bunt-cure Bunt-no-more C₆Cl₆ (hexachloro-benze CEKU C.B. CO-OP Hexa Co-op Hexa Esaclorobenzene Granox NM HCB HCB (pesticide) HCB(R) HEXACHLOROBENZENE Hexa C.B. Hexa c. Hexachlorbenzd Hexachlorbenzol Hexachlorobenzene {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
CAS Number	118-74-1
PubChem Substance ID	8370
EC Number	204-273-9
Beilstein Registry Number	1912585
MDL Number	-
Chemical Name Translation	六氯苯
Merck Number	13,4696
Wiswesser Line Notation	GR BG CG DG EG FG
LabNetwork Molecule ID	LN01245549
InChI	InChI=1S/C6Cl6/c7-1-2(8)4(10)6(12)5(11)3(1)9
Canonical SMILES	-

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分类

2000/60/EC, Alpha sort, Alphabetic, Analytical Standards, Analytical/Chromatography, Aromatics, Baby Food Directives 13/2003 EC & 14/2003 EC, Chromatography, Environmental Standards, European Community: ISO, DIN and DL 152, Fungicides, H, H-M, HA -HT, Market Segments, Method Specific, Neats and Solutions, Oeko-Tex Standard 100, Persistant Organic Pollutants (POPs), Pesticides, Pesticides & Metabolites, Standards for Environmental Analysis
{uni_hamburg} no charge; carbocycle; aromatic; 6RingOnly; 6ring; 1fragment
{SNA} 2000/60/EC, Alphabetic,

产品应用

有机微量分析测定高含量氯的标准。有机合成。杀虫剂。用作拌种杀菌剂，可防治小麦腥黑穗病和杆黑穗病。用于生产花炮，作焰火色剂。还用作五氯酚及五氯酚钠的原料。

安全信息

GHS Symbol

WGK Germany3

Hazard Codes T,N T,N,Xn,F,Xi T;N

Hazard statements

H350 May cause cancer 可能致癌
H372 Causes damage to organs through prolonged or repeated exposure 长期或频繁接触会损伤器官
H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

RTECSDA2975000

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P263 Avoid contact during pregnancy/while nursing. 怀孕/哺乳期间避免接触。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P273 Avoid release to the environment. 避免释放到环境中。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P304+P312
P304+P340
P308+P313
P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医，如果你觉得不舒服
P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Signal word Danger

Safety Statements

S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
S9 Keep container in a well-ventilated place 保持容器在通风良好的场所；
S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
S33 Take precautionary measures against static discharges 对静电采取预防措施；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S29 Do not empty into drains 不要排入下水道；
S62 If swallowed, do not induce vomiting: seek medical advice immediately and show this container or label where possible 吞食后不要催吐：立即求医并出示该容器或标签；

Risk Statements

R45 May cause cancer 可能致癌
R48/25
R50/53
R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
R48/20
R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
R11 Highly flammable 非常易燃
R38 Irritating to skin 刺激皮肤
R62 Possible risk of impaired fertility 有削弱生殖能力的危险
R39/23/24/25 Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed 毒性：吸入，皮肤接触和吞食都会产生十分严重的不可逆危险
R67 Vapours may cause drowsiness and dizziness 蒸汽可能导致嗜睡和昏厥
R51/53
R65 Harmful: may cause lung damage if swallowed 若吞咽可能伤害肺部器官
R66 Repeated exposure may cause skin dryness or cracking 反复接触可能导致皮肤干燥或皴裂

UN Number 2729 UN 2729 6.1/PG 3

Packing GroupIII

Hazard Class6.1(b)

Storage condition 4 4°C APPROX 4°C 储存温度 2-8°C 储存温度2-8℃ 室温、避光保存。室温储存密封阴凉保存。

Warnings 危化品目录(2015)

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 6300 mg/kg/90W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 6,631,1985

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2738 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Kidney, Ureter, Bladder - Kidney tumors
   Blood - leukemia
REFERENCE :
   PAACA3 Proceedings of the American Association for Cancer Research. (Waverly
   Press, 428 E. Preston St., Baltimore, M

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5475 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
   Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
   PAACA3 Proceedings of the American Association for Cancer Research. (Waverly
   Press, 428 E. Preston St., Baltimore, MD 21202)  V.1-    1954-
   Volume(issue)/page/year: 24,59,1983

TYPE OF TEST            : TDLo - Lowest published

TYPE OF TEST

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - hamster
DOSE/DURATION           : 1000 mg/kg/18W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
   Endocrine - thyroid tumors
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 269,510,1977

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 220 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M.,
   Springfield, IL, C.C. Thomas, 1970  Volume(issue)/page/year: 2,73,1970

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
   Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
   GKNT, 1982  Volume(issue)/page/year: -,72,1982

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3600 mg/m3
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
   Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
   GKNT, 1982  Volume(issue)/page/year: -,72,1982

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 1600 mg/m3
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
   Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
   GKNT, 1982  Volume(issue)/page/year: -,72,1982

TYPE OF TEST

{hazard

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 6 mg/L
REFERENCE :
   BLFSBY Basic Life Sciences.  (Plenum Pub. Corp., 223 Spring St., New York,
   NY 10003)  V.1-    1973-  Volume(issue)/page/year: 39,359,1986

TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 20 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 89,95,1981

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 100 ppm
REFERENCE :
   RSTUDV Rivista di Scienza e Technologia degli Alimenti e di Nutrizione
   Umana.  Review of Science and Technology of Food and Human Nutrition.
   (Bologna, Italy)  V.5-6, 1975-76.  Discontinued.  Volume(issue)/page/year:
   6,161,1976

TYPE OF TEST            : Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 1 gm/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 343,157,1995

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 40 mg/kg
SEX/DURATION            : female 10-13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   29,109,1974

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 812 mg/kg
SEX/DURATION            : multigenerations
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
   alive at weaning per # alive at day 4)
REFERENCE :
   AECTCV Archives of Environmental Contamination and Toxicology.
   (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
   070944)  V.1-    1973-  Volume(issue)/page/year: 5,207,1977

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 88 mg/kg
SEX/DURATION            : male 70 day(s) pre-mating
                          female 70 day(s) pre-mating  - 22 day(s) after
                          conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   32OAAP "Pesticide and the Environment: a Continuing Controversy, Selected
   Papers Presented and Papers Reviewed at the 8th Inter-American Conference on
   Toxicology and Occupational Medicine, Miami, FL, 1973," Deichmann, W.B.,
   ed., New York, Stratton Intercontinental Medical Book Corp., 1973
   Volume(issue)/page/year: -,189,1973

TYPE OF TEST            : TDLo - Lowest published toxic dose

Restrict 危险品

其他信息

上游原料:盐酸 --> 三氯苯 --> 氯化塔
毒性分级:中毒
用途一:用作拌种杀菌剂，可防治小麦腥黑穗病和杆黑穗病，还可用作焰火着色剂及生产五氯酚及五氯酚钠的原料
防护措施:本品毒性是氯苯中最低的，但对粘膜有刺激作用，能引起皮肤炎症，损害肝、甲状腺等。大鼠经口LD50为10g/kg。应避免与皮肤接触，防止由口鼻吸入，操作人员宜戴口罩及橡胶手套。
类别:农药
急性毒性:口服-大鼠 LD50: 10000 毫克/公斤; 口服-小鼠 LD50: 4000 毫克/公斤
能升华。溶于苯、氯仿和乙醚，微溶于乙醇，不溶于水。低毒，半数致死量(大鼠，经口)3500mg/kg。有致癌可能性。
下游产品:五氯酚钠 --> 五氯苯硫酚
用途三:用作拌种杀菌剂，可防治小麦腥黑穗病和杆黑穗病。用于生产花炮，作焰火色剂。还用作五氯酚及五氯酚钠的原料。
常规方法:铁桶内衬塑料袋包装，附有规定的有毒标志，贮于通风、干燥处，防潮和雨淋，不得与食物、种子混放，保持包装完整。
储运特性:库房通风低温干燥; 与食品原料分开储运
Sigma Aldrich:118-74-1(sigmaaldrich)
能升华。溶于苯、氯仿和乙醚，微溶于乙醇，不溶于水。低毒，半数致死量(大鼠，经口)3500mg/kg。有致癌可能性
急救治疗:[1]无特殊解毒剂，如经口摄入要催吐 [2]尽可能保持病人安静，控制病人激动。清醒时可给予常用剂量的巴比妥与其它镇静剂 [3]注意维持呼吸，如有衰竭使用人工呼吸 [4]禁忌用肾上腺素或阿托品
MOL 文件:118-74-1.mol
职业标准:TWA 0.5 毫克/立方米; STEL 0.9 毫克/立方米
中毒症状:症状与体征是其对神经系统的刺激作用所致，如头痛、眩晕、忧虑烦恼、情绪激动，也有呕吐、四肢软弱，双手震颤、失去时间和空间的定向，随后出现振发痉挛。
可燃性危险特性:燃烧产生有毒氯化物气体
用途二:有机元素微量分析时用做氯的标准，也用于有机合成
杀虫剂单一组分标准液
灭火剂:雾状水、泡沫、二氧化碳、砂土。
MSDS 信息:六氯苯(118-74-1).msds
外观性质:纯品为无色细针状或小片状晶体, 工业品为淡黄色或淡棕色晶体。
用途四:有机微量分析测定高含量氯的标准。有机合成。杀虫剂。用作拌种杀菌剂，可防治小麦腥黑穗病和杆黑穗病。用于生产花炮，作焰火色剂。还用作五氯酚及五氯酚钠的原料。用于ICP-AES、AAS、AFS、ICP-MS、离子色谱等。滴定分析用标准溶液。校准仪器和装置；评价方法；工作标准；质量保证/质量控制；其他，
方法一:工业生产中，六氯苯主要由苯或低级氯苯直接氯化制得。低级氯苯主要是指生产一氯苯时的副产物二氯苯及从六六六无效体制得的三氯苯而言。也可由六六六无效体直接氯化制得。1.三氯苯氯法将三氯苯加热至110℃，保温干燥1h，能氯气氯化，反应时放出热量，起始温度100-120℃，最终温度为260-270℃，氯化10-14h，当温度开始下降时即表示氯化反应已达终点，停止通氯，将熔融的物料放入盛水的结晶箱，搅拌下六氯苯结晶成粒。用冷水洗涤，即得六氯苯。2.六六六无效体直接氯化法无效体经热风干燥至含水量在1%以下，加入熔融釜中，加热至150-170℃熔化，然后加入洗涤器和氯化塔。洗涤器温度保持在210-230℃，氯化塔通氯后，依照反应热慢慢升温，控制通氯速度，使反应温度每小时上升2-3℃。氯化塔的含氯尾气通入洗涤器吸收后送至副产盐酸系统。当氯化温度达260-270℃，并迅速放入盛水的结晶罐中骤冷结晶即得成品。