2-Bromo-4’-methoxyacetophenone alpha-溴-4-甲氧基苯乙酮
CAS 2632-13-5 MFCD00000201
化学结构图
SMILES: COC1C=CC(=CC=1)C(=O)CBr
化学属性
| Mol. Formula | C9H9BrO2 |
|---|---|
| Mol. Weight | 229.07 |
| Density | 1.448 |
| Melting Point | 69-72°C |
| TSCA | No |
| Boiling Point | 306.7°C at 760 mmHg |
别名和识别编码
| Chemical Name | 2-Bromo-4’-methoxyacetophenone |
|---|---|
| CAS Number | 2632-13-5 |
| Synonym | PTP inhibitor 1 {LY} PTP inhibitor 1 {} {LY} PTP inhibitor 1 {} {} {LY} PTP inhibitor 1 {} {} {} {LY} PTP inhibitor 1 {} {} {} {} {LY} PTP inhibitor 1 {} {} {} {} {} {LY} PTP inhibitor 1 {} {} {} {} {} {} {LY} PTP inhibitor 1 {} {} {} {} {} {} {} {LY} PTP inhibitor 1 {} {} {} {} {} {} {} {} {LY} PTP inhibitor 1 {} {} {} {} {} {} {} {} {} {LY} PTP inhibitor 1 {} {} {} {} {} {} {} {} {} {} {LY} PTP inhibitor 1 {} {} {} {} {} {} {} {} {} {} {} {LY} PTP inhibitor 1 {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} PTP inhibitor 1 {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} PTP inhibitor 1 {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} PTP inhibitor 1 {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} PTP inhibitor 1 {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} PTP inhibitor 1 {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} PTP inhibitor 1 {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} |
| MDL Number | MFCD00000201 |
| EC Number | 220-118-8 |
| Beilstein Registry Number | 743112 |
| PubChem Substance ID | 87572980 |
| Reaxys-RN | 743112 |
| Chemical Name Translation | alpha-溴-4-甲氧基苯乙酮 |
| InChIKey | XQJAHBHCLXUGEP-UHFFFAOYSA-N |
| LabNetwork Molecule ID | LN00220084 |
| Canonical SMILES | COC1=CC=C(C(CBr)=O)C=C1 |
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信息真实价格透明
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分类
- {SNA} Building Blocks, C9, Carbonyl Compounds, Chemical Synthesis, Ketones, Organic Building Blocks
- {SNA} B, Bioactive Small Molecule Alphabetical Index, Building Blocks, C9, Carbonyl Compounds, Chemical Synthesis, Ketones,
产品应用
- 2-Bromo-4'-methoxyacetophenone is a ?-haloacetophenone derivatives tested for inhibition of protein tyrosine phosphatases SHP-1 and PTP1B.
相关文献及参考
- Beilstein:8(4)351
- Elchelby, M., et al.: Science, 283, 1544 (1999),
- Reagent for protection of carboxylic acids as 4-methoxyphenacyl esters, which may be prepared in the presence of KF as base: Synthesis, 897 (1981) and can be cleaved photolytically: J. Org. Chem., 38, 3771 (1973). Peptide bonds are generally unaffected by irradiation but some cleavage of trityl protecting groups may occur. See also Appendix 6. For further discussion of this and other photo-removable protecting groups, see: Synthesis, 1 (1980); Org. Photochem., 9, 225 (1987).
- Shen, K., et al.: J. Biol. Chem., 276, 47311 (2001),
- Taylor, W., et al.: Bioorg. Med. Chem., 4, 1515 (1996),
- [1]. Sylvest L, et al. Phosphatase inhibitors with anti-angiogenic effect in vitro. APMIS. 2010 Jan;118(1):49-59.
安全信息
GHS Symbol
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S27 Take off immediately all contaminated clothing 立即脱掉全部污染的衣服；
- S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护；
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- R34 Causes burns 会导致灼伤
- R36/37 Irritating to eyes and respiratory system 对眼睛和呼吸系统有刺激性
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P301+P330+P331+P310
- P303+P361+P353
- P304+P340+P310
- P305+P351+P338
- P305+P351+P338+P310
- P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H290 May be corrosive to metals 可能腐蚀金属。
- H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
- H335 May cause respiratory irritation 可能导致呼吸道刺激
