PPQ-102 7,9-二甲基-6-(5-甲基呋喃-2-基)-11-苯基-5,6-二氢嘧啶并[4',5':3,4]吡咯并[1,2-a]喹喔啉-8,10(7H,9H)-二酮
CAS 931706-15-9 MFCD031706159
化学结构图
SMILES: Cc1ccc(C2Nc3ccccc3-n3c(-c4ccccc4)c4c(=O)n(C)c(=O)n(C)c4c32)o1
化学属性
| Mol. Formula | C26H22N4O3 |
|---|---|
| Mol. Weight | 438.48 |
| Appearance | white to off-white solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | PPQ-102 |
|---|---|
| Chemical Name Translation | 7,9-二甲基-6-(5-甲基呋喃-2-基)-11-苯基-5,6-二氢嘧啶并[4',5':3,4]吡咯并[1,2-a]喹喔啉-8,10(7H,9H)-二酮 |
| Chemicalbook ID | CB82628279 |
| Formula | C26H22N4O3 |
| Synonym | PPQ102; PPQ 102; PPQ-102. |
| IUPAC Name | 7,9-dimethyl-6-(5-methylfuran-2-yl)-11-phenyl-5,6-dihydropyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(7H,9H)-dione |
| InChIKey | MNOOVRNGPIWJDI-UHFFFAOYSA-N |
| InChI | InChI=1S/C26H22N4O3/c1-15-13-14-19(33-15)21-24-23-20(25(31)29(3)26(32)28(23)2)22(16-9-5-4-6-10-16)30(24)18-12-8-7-11-17(18)27-21/h4-14,21,27H,1-3H3 |
| Canonical SMILES | O=C1N(C)C(C(C(N1C)=O)=C2C3=CC=CC=C3)=C4N2C5=C(C=CC=C5)NC4C6=CC=C(C)O6 |
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产品应用
- PPQ-102 is a potent and selective CFTR inhibitor. PPQ-102, completely inhibited CFTR chloride current with IC(50) approximately 90 nM. Patch-clamp analysis confirmed voltage-independent CFTR inhibition by PPQ-102 and showed stabilization of the channel closed state. PPQ-102 prevented cyst expansion and reduced the size of preformed cysts in a neonatal kidney organ culture model of polycystic kidney disease. PPQ-102 is the most potent CFTR inhibitor identified to date.
