CAS 914913-88-5 MFCD014913885-8-(1-Hydroxyethyl)-2-Methoxy-3-((4-Methoxybenzyl)Oxy)-6H-Benzo[c]Chromen-6-One 8-(1-羟乙基)-2-甲氧基-3-((4-甲氧基苄基)氧基)-6H-苯并[c]苯并吡喃-6-酮 TAO{mole}

SMILES: COc1ccc(COc2cc3oc(=O)c4cc(C(C)O)ccc4c3cc2OC)cc1

Chemical Name	8-(1-Hydroxyethyl)-2-Methoxy-3-((4-Methoxybenzyl)Oxy)-6H-Benzo[c]Chromen-6-One
Chemical Name Translation	8-(1-羟乙基)-2-甲氧基-3-((4-甲氧基苄基)氧基)-6H-苯并[c]苯并吡喃-6-酮
Chemicalbook ID	CB52546569
Formula	C24H22O6
Synonym	Palomid 529; Palomid-529; Palomid529; P529; P 529; P-529.
IUPAC Name	8-(1-hydroxyethyl)-2-methoxy-3-((4-methoxybenzyl)oxy)-6H-benzo[c]chromen-6-one
InChIKey	YEAHTLOYHVWAKW-UHFFFAOYSA-N
InChI	InChI=1S/C24H22O6/c1-14(25)16-6-9-18-19-11-22(28-3)23(12-21(19)30-24(26)20(18)10-16)29-13-15-4-7-17(27-2)8-5-15/h4-12,14,25H,13H2,1-3H3
Canonical SMILES	O=C1C2=CC(C(O)C)=CC=C2C3=C(O1)C=C(OCC4=CC=C(OC)C=C4)C(OC)=C3
MDL Number	N/A
CAS Number	914913-88-5

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Palomid 529, also known as P529, is a novel PI3K/Akt/mTOR inhibitor. Palomid 529 (P529) inhibits the TORC1 and TORC2 complexes and shows both inhibition of Akt signaling and mTOR signaling similarly in tumor and vasculature. It was demonstrated that P529 inhibited tumor growth, angiogenesis, and vascular permeability. It retained the beneficial aspects of tumor vascular normalization that rapamycin boasts. However, P529 showed the additional benefit of blocking pAktS473 signaling consistent with blocking TORC2 in all cells and thus bypassing feedback loops that lead to increased Akt signaling in some tumor cells. (Source: Cancer Res 008;68(22):9551Â–7).

GHS Symbol

UN Number 2811

Hazard Codes 6.1

Signal word Danger

Precautionary statements

Packing GroupIII

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

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