Protamine sulfate, from milt Protamine sulfate
CAS 9009-65-8 MFCD09009658
化学结构图
SMILES:
化学属性
| Mol. Weight | |
|---|---|
| Mol. Formula | N/A |
别名和识别编码
| Chemical Name | Protamine sulfate, from milt |
|---|---|
| Chemical Name Translation | Protamine sulfate |
| Chemicalbook ID | CB7727744 |
| Synonym | Angiociclan Dilangio Vasorelax Fluxema USAF D-4 |
| CAS Number | 9009-65-8 |
| MDL Number | MFCD00132091 |
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相关文献及参考
- [2]. F L Sorgi, et al. Protamine sulfate enhances lipid-mediated gene transfer. Gene Ther. 1997 Sep;4(9):961-8.
- [3]. R J Cobel-Geard, et al. Interaction of protamine sulfate with thrombin. Am J Hematol. 1983 May;14(3):227-33.
- [4]. Fionnuala Ni Ainle, et al. Protamine sulfate down-regulates thrombin generation by inhibiting factor V activation. Blood. 2009 Aug 20;114(8):1658-65.
- [1]. Ahmed Kouta, et al. Protamine Sulfate Neutralization Profile of Various Dosages of Bovine, Ovine and Porcine UFHs and Their Depolymerized Derivatives in Non-Human Primates. Clin Appl Thromb Hemost. Jan-Dec 2021;27:10760296211005544.
- [1]. Ahmed Kouta, et al. Protamine Sulfate Neutralization Profile of Various Dosages of Bovine, Ovine and Porcine UFHs and Their Depolymerized Derivatives in Non-Human Primates. Clin Appl Thromb Hemost. Jan-Dec 2021;27:10760296211005544.
- [2]. F L Sorgi, et al. Protamine sulfate enhances lipid-mediated gene transfer. Gene Ther.
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 38 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 38,73,1975
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 75 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - cyanosis REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 165,374,1967
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 120 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,726,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 120 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,726,1982
TYPE OF TEST : LD50 - Lethal dose, 50 p
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rat DOSE : 60 mg/kg SEX/DURATION : female 21 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - delayed effects REFERENCE : MORFEU Morfologiya. (Mezhdunarodnaya Kniga, Bd'shaya Yakimanka, 39 117049 Moscow, Russia) V.102- 1992- Volume(issue)/page/year: 112(4),67,1997
GHS Symbol
