Heparin

CAS 9005-49-6 MFCD09005496

化学结构图

9005-49-6
SMILES: CC(=O)NC1C(O)OC(COS(=O)(=O)O)C(OC2OC(C(=O)O)C(OC3OC(CO)C(OC4OC(C(=O)O)C(O)C(O)C4OS(=O)(=O)O)C(OS(=O)(=O)O)C3NS(=O)(=O)O)C(O)C2OS(=O)(=O)O)C1O

别名和识别编码

InChIKeyHTTJABKRGRZYRN-UHFFFAOYSA-N
Chemical NameHeparin
Synonym Sublingula Vitrum AB Pabyrin CY 216 Thromboliquine FR 860 Heparin sulfate Novoheparin Clexane Fraxiparin Lipo-hepin Enoxaparin Lovenox Vetren alpha-Heparin Heparinic acid KB 101 CY 222 Heparinate Sandoparin
CAS Number9005-49-6
PubChem Substance ID772
InChIInChI=1S/C26H42N2O37S5/c1-4(30)27-7-9(31)13(6(56-23(7)39)3-55-67(43,44)45)58-26-19(65-70(52,53)54)12(34)16(20(62-26)22(37)38)60-24-8(28-66(40,41)42)15(63-68(46,47)48)14(5(2-29)57-24)59-25-18(64-69(49,50)51)11(33)10(32)17(61-25)21(35)36/h5-20,23-26,28-29,31-34,39H,2-3H2,1H3,(H,27,30)(H,35,36)(H,37,38)(H,40,41,42)(H,43,44,45)(H,46,47,48)(H,49,50,51)(H,52,53,54)
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相关文献及参考

  • [2]. Anurag Purushothaman, et al. Fibronectin on the Surface of Myeloma Cell-derived Exosomes Mediates Exosome-Cell Interactions. J Biol Chem. 2016 Jan 22;291(4):1652-63.
  • [1]. Capila I, et al. Heparin-protein interactions. Angew Chem Int Ed Engl. 2002 Feb 1;41(3):391-412.
  • [1]. Capila I, et al. Heparin-protein interactions. Angew Chem Int Ed Engl. 2002 Feb 1;41(3):391-412.
  • [2]. Anurag Purushothaman, et al. Fibronectin on the Surface of Myeloma Cell-derived Exosomes Mediates Exosome-Cell Interactions. J Biol Chem. 2016 Jan 22;291(4):1652-63.

安全信息

RTECSMI0700000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1950 mg/kg
TOXIC EFFECTS :

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 3536 units/kg/13D-I
TOXIC EFFECTS :
   Nutritional and Gross Metabolic - changes in potassium
REFERENCE :
   SMJOAV Southern Medical Journal.  (Southern Medical Assoc., POB 2446,
   Birmingham, AL 35205) V.1-    1908-  Volume(issue)/page/year: 80,1450,1987

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 420 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 36,1366,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1950 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other tha

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 1857 units/kg

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Ascites tumor
DOSE/DURATION           : 42 mg/L
REFERENCE :
   AMOKAG Acta Medicia Okayama.  (Okayama Univ. Medical School, Okayama, Japan)
    V.27    1973-  Volume(issue)/page/year: 33,149,1979

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 1 mg/L
REFERENCE :
   NNBYA7 Nature (London), New Biology.  (Basingstoke, Hants., UK)  V.229-246,
   1971-73.  For publisher information, see NATUAS.  Volume(issue)/page/year:
   232,143,1971

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - guinea pig Bone marrow
DOSE/DURATION           : 5 mg/L
REFERENCE :
   FOBLAN Folia Biologica (Prague).  (Academic Press Inc. Ltd., 24-28 Oval Rd.,
   London NW1 7DX, UK) V.1-    1955-  Volume(issue)/page/year: 16,196,1970

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 20 ug
REFERENCE :
   BBACAQ Biochimica et Biophysica Acta.  (Elsevier Science Pub. B.V., POB 211,
   1000 AE Amsterdam, Netherlands)  V.1-    1947- Volume(issue)/page/year:
   479,391,1977

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION           : 10 mg/L
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(issue)/page/year: 71,615,1983

TY

TYPE OF TEST

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - mouse Liver
DOSE/DURATION           : 33 mg/L
REFERENCE :
   AMOKAG Acta Medicia Okayama.  (Okayama Univ. Medical School, Okayama, Japan)
    V.27    1973-  Volume(issue)/page/year: 33,149,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - man
DOSE                    : 2857 units/kg
SEX/DURATION            : male 5 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - other effects on male
REFERENCE :
   PGMJAO Postgraduate Medical Journal.  (Blackwell Scientific Pub. Ltd., POB
   88, Oxford, UK) V.1-    1925-  Volume(issue)/page/year: 59,332,1983

系列性分类

  1. Medical Research Areas
  2. Metabolism
  3. Thrombin  (凝血酶)
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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