N-[2-(Dimethylamino)Ethyl]-12-Oxo-2H-Benzo[G]Pyrido[2,1-B]Quinazoline-4-Carboxamide N-[2-(二甲基氨基)乙基]-12-氧代-12H-苯并[G]吡啶并[2,1-B]喹唑啉-4-甲酰胺
CAS 896705-16-1 MFCD96705161
化学结构图
SMILES: CN(C)CCNC(=O)C1=CC=CN2C(=O)C3C=c4ccccc4=CC3N=C12
化学属性
| Mol. Weight | 362.43 |
|---|---|
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name Translation | N-[2-(二甲基氨基)乙基]-12-氧代-12H-苯并[G]吡啶并[2,1-B]喹唑啉-4-甲酰胺 |
|---|---|
| Chemical Name | N-[2-(Dimethylamino)Ethyl]-12-Oxo-2H-Benzo[G]Pyrido[2,1-B]Quinazoline-4-Carboxamide |
| Formula | C21H22N4O2 |
| Synonym | BMH21; BMH 21; BMH-21. |
| IUPAC Name | N-(2-(dimethylamino)ethyl)-12-oxo-11a,12-dihydro-5aH-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide |
| InChIKey | FSCFXXLAGKOPMP-UHFFFAOYSA-N |
| InChI | InChI=1S/C21H22N4O2/c1-24(2)11-9-22-20(26)16-8-5-10-25-19(16)23-18-13-15-7-4-3-6-14(15)12-17(18)21(25)27/h3-8,10,12-13,17-18H,9,11H2,1-2H3,(H,22,26) |
| Canonical SMILES | O=C(C1=CC=CN2C1=NC3C=C(C=CC=C4)C4=CC3C2=O)NCCN(C)C |
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产品应用
- BMH-21 is a potent small molecule DNA intercalator. BMH-21 binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription. BMH-21 does not cause phosphorylation of H2AX, a key biomarker activated in DNA damage stress. BMH-21 effects on the nucleolar stress response were independent of major DNA damage associated PI3-kinase pathways, ATM, ATR and DNA-PKcs. BMH-21 is a chemically unique DNA intercalator that has high bioactivity towards Pol I inhibition without activation or dependence of DNA damage stress. The findings also show that interference with DNA and DNA metabolic processes can be exploited therapeutically without causing DNA damage.
