AP23846
CAS 878654-51-4 MFCD78654514
化学结构图
SMILES: CCCP(=O)(CCC)c1ccc(Nc2nc(C3CCCC3)nc3c2ncn3CC)cc1
化学属性
| Mol. Weight | 439.53 |
|---|---|
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | AP23846 |
|---|---|
| Formula | C24H34N5OP |
| Synonym | AP23846; AP 23846; AP-23846 |
| IUPAC Name | (4-((2-cyclopentyl-9-ethyl-9H-purin-6-yl)amino)phenyl)dipropylphosphine oxide |
| InChIKey | QWYGJEVWFGFNRP-UHFFFAOYSA-N |
| InChI | InChI=1S/C24H34N5OP/c1-4-15-31(30,16-5-2)20-13-11-19(12-14-20)26-23-21-24(29(6-3)17-25-21)28-22(27-23)18-9-7-8-10-18/h11-14,17-18H,4-10,15-16H2,1-3H3,(H,26,27,28) |
| Canonical SMILES | CCCP(CCC)(C1=CC=C(NC2=C3N=CN(CC)C3=NC(C4CCCC4)=N2)C=C1)=O |
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产品应用
- AP23846 is a potent c-Src kinase inhibitor (IC50 approximately 0.5 nmol/L in vitro, approximately 10-fold more potent than PP2, the most widely used commercially available Src family kinase inhibitor). At concentrations of 1 micromol/L, AP23846 led to complete Src inhibition for 48 hours in cells. No cytotoxicity was observed under these conditions, although proliferation rates were slower. Therefore, this was an excellent inhibitor to examine Src-regulated signaling pathways in tumor cells. AP23846 reduced cellular migration, vascular endothelial growth factor, and interleukin-8 in a dose-dependent fashion in pancreatic adenocarcinoma cells grown in vitro.
