Ivacaftor 依伐卡托
CAS 873054-44-5 MFCD73054445
化学结构图
SMILES: CC(C)(C)c1cc(C(C)(C)C)c(NC(=O)c2c[nH]c3ccccc3c2=O)cc1O
化学属性
| Mol. Weight | 392 |
|---|---|
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
| Mol. Formula | C24H28N2O3 |
别名和识别编码
| Chemical Name | Ivacaftor |
|---|---|
| Synonym | VX-770 VX770; VX 770; VX-770; Ivacaftor; brand name: KALYDECO; Orkambi. |
| Chemical Name Translation | 依伐卡托 |
| Formula | C24H28N2O3 |
| IUPAC Name | N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide |
| InChIKey | PURKAOJPTOLRMP-UHFFFAOYSA-N |
| InChI | InChI=1S/C24H28N2O3/c1-23(2,3)16-11-17(24(4,5)6)20(27)12-19(16)26-22(29)15-13-25-18-10-8-7-9-14(18)21(15)28/h7-13,27H,1-6H3,(H,25,28)(H,26,29) |
| Canonical SMILES | O=C(C1=CNC2=C(C=CC=C2)C1=O)NC3=CC(O)=C(C(C)(C)C)C=C3C(C)(C)C |
| MDL Number | N/A |
| CAS Number | 873054-44-5 |
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产品应用
- Ivacaftor, also known as VX-770, is a drug used to treat cystic fibrosis in people with certain mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, who account for 4–5% cases of cystic fibrosis, and is included in a combination drug, lumacaftor/ivacaftor, which is used to treat people with cystic fibrosis who have the F508del mutation in CFTR. Ivacaftor is a "potentiator" of CFTR, meaning it increases the probability that the defective channel will be open and allow chloride ions pass through the channel pore.
安全信息
GHS Symbol
