CEP-14513 is a potent ALK inhibitor. CEP-14513 displayed potent ALK inhibitory activity in both in vitro enzymatic assay (IC50 = 5 nM) and cell-based assays of ALK tyrosine phosphorylation (IC50 = 30 nM).
CAS 856693-04-4 MFCD56693044
化学结构图
SMILES: CC(C)Cn1c2ccc(OC(=O)NCc3ccc(N(C)C)cc3)cc2c2c3c(c4c(c21)CCc1nn(C)cc1-4)C(=O)NC3
化学属性
| Mol. Weight | 576.69 |
|---|---|
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | CEP-14513 is a potent ALK inhibitor. CEP-14513 displayed potent ALK inhibitory activity in both in vitro enzymatic assay (IC50 = 5 nM) and cell-based assays of ALK tyrosine phosphorylation (IC50 = 30 nM). |
|---|---|
| Formula | C34H36N6O3 |
| Synonym | CEP14513; CEP 14513; CEP-14513. |
| IUPAC Name | 13-isobutyl-4-methyl-6-oxo-2,4,6,7,8,13-hexahydro-1H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-10-yl 4-(dimethylamino)benzylcarbamate |
| InChIKey | ZFKJDNACAGAYFJ-UHFFFAOYSA-N |
| InChI | InChI=1S/C34H36N6O3/c1-19(2)17-40-28-13-10-22(43-34(42)36-15-20-6-8-21(9-7-20)38(3)4)14-24(28)30-25-16-35-33(41)31(25)29-23(32(30)40)11-12-27-26(29)18-39(5)37-27/h6-10,13-14,18-19H,11-12,15-17H2,1-5H3,(H,35,41)(H,36,42) |
| Canonical SMILES | O=C(OC1=CC=C(N(CC(C)C)C2=C3C4=C(C(NC4)=O)C5=C2CCC6=NN(C)C=C65)C3=C1)NCC7=CC=C(N(C)C)C=C7 |
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- CEP-14513 is a potent ALK inhibitor. CEP-14513 displayed potent ALK inhibitory activity in both in vitro enzymatic assay (IC50 = 5 nM) and cell-based assays of ALK tyrosine phosphorylation (IC50 = 30 nM).
