CEP-11981
CAS 856691-93-5 MFCD56691935
化学结构图
SMILES: CC(C)Cn1c2ccc(Nc3ncccn3)cc2c2c3c(c4c(c21)CCc1nn(C)cc1-4)C(=O)NC3
化学属性
| Mol. Weight | 477.56 |
|---|---|
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | CEP-11981 |
|---|---|
| Formula | C28H27N7O |
| Synonym | CEP11981; CEP 11981; CEP11981 |
| IUPAC Name | 13-isobutyl-4-methyl-10-(pyrimidin-2-ylamino)-4,7,8,13-tetrahydro-1H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-6(2H)-one |
| InChIKey | AEULIVPVIDOLIN-UHFFFAOYSA-N |
| InChI | InChI=1S/C28H27N7O/c1-15(2)13-35-22-8-5-16(32-28-29-9-4-10-30-28)11-18(22)24-19-12-31-27(36)25(19)23-17(26(24)35)6-7-21-20(23)14-34(3)33-21/h4-5,8-11,14-15H,6-7,12-13H2,1-3H3,(H,31,36)(H,29,30,32) |
| Canonical SMILES | O=C1NCC2=C1C(C3=CN(C)N=C3CC4)=C4C(N5CC(C)C)=C2C6=C5C=CC(NC7=NC=CC=N7)=C6 |
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产品应用
- CEP-11981 is an orally bioavailable inhibitor of vascular endothelial growth factor receptor (VEGFR) and Tie2 receptor tyrosine kinases with potential antiangiogenic and antineoplastic activities. Pan-VEGFR/Tie2 tyrosine kinase inhibitor CEP-11981 selectively binds to VEGFR and Tie2 receptor tyrosine kinases, which may result the inhibition of endothelial cell migration, proliferation and survival and the inhibition of tumor cell proliferation and tumor cell death.
