L-Cysteinamide,D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl- N-(2-hydroxy-1-(hydroxymethyl)propyl)-,cyclic(2-7)-disulfide, (R-(R*,R*))-, acetate (salt)
CAS 79517-01-4 MFCD79517014
化学结构图
SMILES: C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC2=CNC3C=CC=CC2=3)NC(=O)[C@H](CC2C=CC=CC=2)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)NC(CO)C(C)O)NC(=O)[C@H](N)CC1C=CC=CC=1
化学属性
| Mol. Weight | 1079 |
|---|---|
| Mol. Formula | C51H70N10O12S2 |
别名和识别编码
| CAS Number | 79517-01-4 |
|---|---|
| Chemical Name | L-Cysteinamide,D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl- N-(2-hydroxy-1-(hydroxymethyl)propyl)-,cyclic(2-7)-disulfide, (R-(R*,R*))-, acetate (salt) |
| Synonym | D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl]- SMS 201-995 Octreotide acetate |
| Chemical Name Translation | |
| MDL Number | MFCD00871400 |
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信息真实价格透明
资金保障
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现货库存
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分类
- Peptides
- Pharmaceuticals
- Intermediates & Fine Chemicals
产品应用
- Octapeptide analog of Somatostatin. A gastric antisecretory agent. Used in treatment of acromegaly.
相关文献及参考
- [2]. Kim S, et al. Treatment of Gastrin-Secreting Tumor With Sustained-Release Octreotide Acetate in a Dog. J Am Anim Hosp Assoc. 2015 Nov-Dec;51(6):407-12.
- Bauer, W., et al.: Life Sci., 31, 1133 (1982),
- Kraenzlin, M.E., et al.: Experientia, 41, 738 (1985),
- Plewe, G., et al.: Lancet, 2, 782 (1984),
- [1]. Wang M, et al. Pharmacokinetic and pharmacodynamic study of a phospholipid-based phase separation gel for once a month administration of octreotide. J Control Release. 2016 May 28;230:45-56.
- [1]. Wang M, et al. Pharmacokinetic and pharmacodynamic study of a phospholipid-based phase separation gel for once a month administration of octreotide. J Control Release. 2016 May 28;230:45-56.
- [2]. Kim S, et al. Treatment of Gastrin-Secreting Tumor With Sustained-Release Octreotide Acetate in a Dog. J Am Anim Hosp Assoc. 2015 Nov-Dec;51(6):407-12.
- del Pozo, E., et al.: Acta Endocrinol., 111, 433 (1986),
安全信息
{hTYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 18100 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 22,967,1991
TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES O
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Human - man DOSE/DURATION : 1429 ug/kg TOXIC EFFECTS : Gastrointestinal - changes in structure or function of endocrine pancreas Liver - liver function tests impaired REFERENCE : LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 348,1668,1996
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 72300 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 22,967,1991
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Human - man DOSE/DURATION : 2587 ug/kg TOXIC EFFECTS : Gastrointestinal - changes in structure or function of endocrine pancreas Liver - liver function tests impaired REFERENCE : LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 348,1668,1996
