MRK560 MRK560
CAS 677772-84-8 MFCD77772848
化学结构图
SMILES: O=S(=O)(N[C@H]1CC[C@](c2cc(F)ccc2F)(S(=O)(=O)c2ccc(Cl)cc2)CC1)C(F)(F)F
化学属性
| Mol. Formula | C19H17ClF5NO4S2 |
|---|---|
| Mol. Weight | 517.92 |
| Appearance | white solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | MRK-560 |
|---|---|
| Chemical Name Translation | MRK560 |
| Chemicalbook ID | CB02538282 |
| Formula | C19H17ClF5NO4S2 |
| Synonym | MRK560; MRK 560; MRK-560 |
| IUPAC Name | N-((1r,4r)-4-((4-chlorophenyl)sulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)-1,1,1-trifluoromethanesulfonamide |
| InChIKey | WDZVWDXOIGQJIO-PPUGGXLSSA-N |
| InChI | InChI=1S/C19H17ClF5NO4S2/c20-12-1-4-15(5-2-12)31(27,28)18(16-11-13(21)3-6-17(16)22)9-7-14(8-10-18)26-32(29,30)19(23,24)25/h1-6,11,14,26H,7-10H2/t14-,18- |
| Canonical SMILES | O=S(C(F)(F)F)(N[C@H]1CC[C@](C2=CC(F)=CC=C2F)(S(=O)(C3=CC=C(Cl)C=C3)=O)CC1)=O |
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产品应用
- MRK-560 is an orally bioavailable gamma-secretase inhibitor with the ability to markedly reduce Abeta peptide in the brain and CSF of the rat and confirm the utility of the rat for assessing the effects of gamma-secretase inhibitors on central nervous system Abeta(40) levels in vivo.
