5-((4-Bromo-2-Fluorophenyl)Amino)-4-Fluoro-N-(2-Hydroxyethoxy)-1-Methyl-1H-Benzo[D]Imidazole-6-Carboxamide 5-((4-溴-2-氟苯基)氨基)-4-氟-N-(2-羟基乙氧基)-1-甲基-1H-苯并[d]咪唑-6-甲酰胺
CAS 606143-89-9 MFCD06143899
化学结构图
SMILES: Cn1cnc2c(F)c(Nc3ccc(Br)cc3F)c(C(=O)NOCCO)cc21
化学属性
| Mol. Weight | 441.22681 |
|---|---|
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name Translation | 5-((4-溴-2-氟苯基)氨基)-4-氟-N-(2-羟基乙氧基)-1-甲基-1H-苯并[d]咪唑-6-甲酰胺 |
|---|---|
| LabNetwork Molecule ID | LN01299028 |
| Chemical Name | 5-((4-Bromo-2-Fluorophenyl)Amino)-4-Fluoro-N-(2-Hydroxyethoxy)-1-Methyl-1H-Benzo[D]Imidazole-6-Carboxamide |
| PubChem Substance ID | 10288191 |
| InChI | InChI=1S/C17H15BrF2N4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26) |
| Synonym | MEK162 MEK162; MEK-162; MEK 162; ARRY162; ARRY-162; ARRY 162; ARRY438162, Binimetinib; Brand name: Mektovi. binimetinib |
| Formula | C17H15BrF2N4O3 |
| IUPAC Name | 5-((4-bromo-2-fluorophenyl)amino)-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzo[d]imidazole-6-carboxamide. |
| InChIKey | ACWZRVQXLIRSDF-UHFFFAOYSA-N |
| Canonical SMILES | O=C(C1=C(NC2=CC=C(Br)C=C2F)C(F)=C3N=CN(C)C3=C1)NOCCO |
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产品应用
- Binimetinib, also known as MEK162 (ARRY-162), is an oral, highly selective MEK inhibitor. In preclinical studies, MEK162 showed significant antitumor activities in cell lines and animal models. MEK162 is the first targeted therapy to show activity in patients with NRAS -mutated melanoma and might offer a new option for a cancer with few effective treatments.
