8-(4-Dibenzothiophenyl)-2-(4-Morpholinyl)-4H-1-Benzopyran-4-One 8-(4-二苯并噻吩基)-2-(4-吗啉基)-4H-1-苯并吡喃-4-酮
CAS 503468-95-9 MFCD03468959
化学结构图
SMILES: O=c1cc(N2CCOCC2)oc2c(-c3cccc4c3sc3ccccc34)cccc12
化学属性
| Mol. Weight | 413.49 |
|---|---|
| Mol. Formula | C25H19NO3S |
| Appearance | Off-white to beige solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| CAS Number | 503468-95-9 |
|---|---|
| Chemical Name | 8-(4-Dibenzothiophenyl)-2-(4-Morpholinyl)-4H-1-Benzopyran-4-One |
| Synonym | 8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one NU7441; NU-7441; NU 7441; KU-57788; KU 57788; KU57788 |
| Chemical Name Translation | 8-(4-二苯并噻吩基)-2-(4-吗啉基)-4H-1-苯并吡喃-4-酮 |
| Formula | C25H19NO3S |
| IUPAC Name | 8-(4-dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one |
| InChIKey | JAMULYFATHSZJM-UHFFFAOYSA-N |
| InChI | InChI=1S/C25H19NO3S/c27-21-15-23(26-11-13-28-14-12-26)29-24-17(6-3-9-20(21)24)19-8-4-7-18-16-5-1-2-10-22(16)30-25(18)19/h1-10,15H,11-14H2 |
| Canonical SMILES | O=C1C=C(N2CCOCC2)OC3=C(C4=C5C(C6=CC=CC=C6S5)=CC=C4)C=CC=C13 |
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分类
- Heterocycles
- Sulfur & Selenium Compounds
- Pharmaceuticals
- Intermediates & Fine Chemicals
产品应用
- NU7441, also known as KU-57788, is a highly potent and selective DNA-PK inhibitor (IC50=14 nM), exhibiting ATP-competitive inhibition kinetics. NU7441 increased the cytotoxicity of ionizing radiation and etoposide in SW620, LoVo, and V3-YAC cells but not in V3 cells, confirming that potentiation was due to DNA-PK inhibition. NU7441 substantially retarded the repair of ionizing radiation-induced and etoposide-induced DSB.
相关文献及参考
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