N-(2-Chloro-5-Methoxyphenyl)-6-Methoxy N-(2-氯-5-甲氧基苯基)-6-甲氧基
CAS 476159-98-5 MFCD76159985
化学结构图
SMILES: COc1ccc(Cl)c(Nc2ncnc3cc(OCC4CCN(C)CC4)c(OC)cc23)c1
化学属性
| Mol. Weight | 442.94 |
|---|---|
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | N-(2-Chloro-5-Methoxyphenyl)-6-Methoxy |
|---|---|
| Formula | C23H27ClN4O3 |
| Synonym | AZM475271; AZM-475271; AZM 475271. |
| IUPAC Name | N-(2-chloro-5-methoxyphenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine |
| InChIKey | WPOXAFXHRJYEIC-UHFFFAOYSA-N |
| InChI | InChI=1S/C23H27ClN4O3/c1-28-8-6-15(7-9-28)13-31-22-12-19-17(11-21(22)30-3)23(26-14-25-19)27-20-10-16(29-2)4-5-18(20)24/h4-5,10-12,14-15H,6-9,13H2,1-3H3,(H,25,26,27) |
| Canonical SMILES | CN1CCC(COC2=CC3=NC=NC(NC4=CC(OC)=CC=C4Cl)=C3C=C2OC)CC1 |
| Chemical Name Translation | N-(2-氯-5-甲氧基苯基)-6-甲氧基 |
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产品应用
- AZM475271 is orally Src tyrosine kinase inhibitor with potential anticancer and antimetastatic activities. Chemical structurally, AZM-475271 is the 4-amino-quinazoline based anticancer agent. AZM475271 remarkably inhibits growth and metastasis of orthotopically implanted human pancreatic carcinoma cells in nude mice. AZM475271 suppresses tumor growth and metastasis in vitro and in vivo potentially by anti-angiogenic mechanisms.
