Syntelin
CAS 438481-33-5 MFCD38481335
化学结构图
SMILES: Nc1nc(SCc2nnc(SCC(=O)O)n2-c2ccccc2)nc2sc3c(c12)CCCC3
化学属性
| Mol. Weight | 484.62 |
|---|---|
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | Syntelin |
|---|---|
| Formula | C21H20N6O2S3 |
| Synonym | Syntelin. |
| IUPAC Name | 2-((5-(((4-amino-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-2-yl)thio)methyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetic acid |
| InChIKey | InChI=1S/C21H20N6O2S3/c22-18-17-13-8-4-5-9-14(13)32-19(17)24-20(23-18)30-10-15-25-26-21(31-11-16(28)29)27(15)12-6-2-1-3-7-12/h1-3,6-7H,4-5,8-11H2,(H,28,29)(H2,22,23,24) |
| InChI | SPRISILOMIVCIR-UHFFFAOYSA-N |
| Canonical SMILES | O=C(O)CSC1=NN=C(CSC2=NC(N)=C(C3=C(CCCC3)S4)C4=N2)N1C5=CC=CC=C5 |
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产品应用
- Syntelin is a selectively CENP-E inhibitor. Syntelin inhibited CENP-E motility in a dose-dependent manner with an IC50 value of 160 nM. Among an extensive list of mitotic kinesins examined, syntelin was found to be highly selective for CENP-E. Syntelin binds to different sites from those of GSK923295, a recently identified CENP-E ATPase inhibitor, as syntelin inhibits CENP-E mutants resistant to GSK923295 in a manner indistinguishable from that of wild type motor. Syntelin represents a novel class of CENP-E motor inhibitor.
