Norgestimate 炔诺肟酯
CAS 35189-28-7 MFCD35189287
化学结构图
SMILES: CC(=O)O[C@]1(CC[C@H]2[C@@H]3CCC4=C/C(/CC[C@@H]4[C@@H]3CC[C@@]12CC)=N/O)C#C
化学属性
| Mol. Weight | 369.55 |
|---|---|
| Mol. Formula | C23H31NO3 |
别名和识别编码
| CAS Number | 35189-28-7 |
|---|---|
| Chemical Name | Norgestimate |
| Synonym | (17α)-17-(Acetyloxy)-13-ethyl-18,19-dinorpregn-4-en-20-yn-3-one 3-oxime Dexnorgestrel acetime (17?)-17-(Acetyloxy)-13-ethyl-18,19-dinorpregn-4-en-20-yn-3-one 3-Oxime (17-alpha)-17-(Acetyloxy)-13-ethyl-18,19-dinorpregn-4-en-20-yn-3-one |
| InChIKey | KIQQMECNKUGGKA-NMYWJIRASA-N |
| Chemical Name Translation | 炔诺肟酯 |
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分类
- Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Hormones, Progesterone, Steroid Hormones
产品应用
- Progestogen. In combination with estrogen as oral contraceptive.
相关文献及参考
- Hahn, D.W., et al.: Contraception, 16, 541 (1977),
- Weintraub, H.S., et al.: J. Pharm. Sci., 67, 1406 (1978),
- Liu, L., et al., Clinically relevant progestins regulate neurogenic and neuroprotective responses in vitro and in vivo . Endocrinology 151 , 5782-5794, (2010)
- Schmitt-Hoffmann, A.H., et al, Influence of alitretinoin on the pharmacokinetics of the oral contraceptive ethinyl estradiol/norgestimate. Clin. Exp. Dermatol. 36 Suppl 2 , 4-11, (2011)
- Fazio, G., et al., Protrhombotic effects of contraceptives. Curr. Pharm. Des. 16 , 3490-3496, (2010)
安全信息
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 1 mg/kg SEX/DURATION : female 2 day(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - other measures of fertility REFERENCE : CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 16,541,1977
