N-(5-Chloropyridin-2-Yl)-2-(4-(N,N-Dimethylcarbamimidoyl)Benzamido)-5-Methoxybenzamide N-(5-氯-2-吡啶基)-2-(4-(N,N-二甲基甲脒基苯甲酰氨基)-5-甲氧基苯甲酰胺
CAS 330942-05-7 MFCD30942057
化学结构图
SMILES: COc1ccc(NC(=O)c2ccc(C(=N)N(C)C)cc2)c(C(=O)Nc2ccc(Cl)cn2)c1
化学属性
| Mol. Weight | 451.91 |
|---|---|
| Mol. Formula | C23H22ClN5O3 |
别名和识别编码
| CAS Number | 330942-05-7 |
|---|---|
| Chemical Name | N-(5-Chloropyridin-2-Yl)-2-(4-(N,N-Dimethylcarbamimidoyl)Benzamido)-5-Methoxybenzamide |
| Synonym | BEVYXXA N-(5-Chloro-2-pyridinyl)-2-[[4-[(dimethylamino)iminomethyl]benzoyl]amino]-5-methoxybenzamide N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide PRT 054021 PRT054021 betrixaban |
| Chemical Name Translation | N-(5-氯-2-吡啶基)-2-(4-(N,N-二甲基甲脒基苯甲酰氨基)-5-甲氧基苯甲酰胺 |
| PubChem Substance ID | 10275777 |
| InChI | InChI=1S/C23H22ClN5O3/c1-29(2)21(25)14-4-6-15(7-5-14)22(30)27-19-10-9-17(32-3)12-18(19)23(31)28-20-11-8-16(24)13-26-20/h4-13,25H,1-3H3,(H,27,30)(H,26,28,31) |
| LabNetwork Molecule ID | LN01283445 |
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分类
- Aromatics
- Heterocycles
- Inhibitors
- Pharmaceuticals
- Intermediates & Fine Chemicals,
产品应用
- A novel anticoagulant. An oral direct inhibitor of factor Xa (FXa) for use in the prevention of venous thromboembolism (VTE).
相关文献及参考
- [2]. Lu G, et al. A specific antidote for reversal of anticoagulation by direct and indirect inhibitors of coagulation factor Xa. Nat Med. 2013 Apr;19(4):446-51.
- Turpie, A.G.G. et al.: Thromb. Haemost., 101, 68 (2009); Gomez-Outes, A. et al.: Curr. Vasc. Pharmacol., 7, 309 (2009);
- [1]. Zhang P, et al. Discovery of Betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor. Bioorg Med Chem Lett. 2009 Apr 15;19(8):21
- [1]. Zhang P, et al. Discovery of Betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor. Bioorg Med Chem Lett. 2009 Apr 15;19(8):21
- [2]. Lu G, et al. A specific antidote for reversal of anticoagulation by direct and indirect inhibitors of coagulation factor Xa. Nat Med. 2013 Apr;19(4):44
安全信息
- H302 Harmful if swallowed 吞食有害
- H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P301+P312
- P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医，如果你觉得不舒服
- P330 Rinse mouth. 漱口
- P501 Dispose of contents/container to..… 处理内容物/容器.....
