AG14361 is a PARP-1 inhibitor with Ki < 5 nmol/L. AG14361 is at least 1000-fold more potent than the benzamides. The IC50 for AG14361 is 29 nM in permeabilized SW620 cells and 14 nM in intact SW620 cells. AG14361
CAS 328543-09-5 MFCD28543095
化学结构图
SMILES: CN(C)Cc1ccc(-c2nc3cccc4c3n2CCNC4=O)cc1
化学属性
| Mol. Formula | C19H20N4O |
|---|---|
| Mol. Weight | 320.3883 |
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | AG14361 is a PARP-1 inhibitor with Ki < 5 nmol/L. AG14361 is at least 1000-fold more potent than the benzamides. The IC50 for AG14361 is 29 nM in permeabilized SW620 cells and 14 nM in intact SW620 cells. |
|---|---|
| Chemical Name Translation | AG14361 |
| Chemicalbook ID | CB72525863 |
| Formula | C19H20N4O |
| Synonym | AG14361; AG-14361; AG 14361. |
| IUPAC Name | 1-(4-((dimethylamino)methyl)phenyl)-8,9-dihydro-2,7,9a-triazabenzo[cd]azulen-6(7H)-one. |
| InChIKey | SEKJSSBJKFLZIT-UHFFFAOYSA-N |
| InChI | InChI=1S/C19H20N4O/c1-22(2)12-13-6-8-14(9-7-13)18-21-16-5-3-4-15-17(16)23(18)11-10-20-19(15)24/h3-9H,10-12H2,1-2H3,(H,20,24) |
| Canonical SMILES | O=C1C2=C3C(N=C(C4=CC=C(CN(C)C)C=C4)N3CCN1)=CC=C2 |
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- AG14361 is a PARP-1 inhibitor with Ki < 5 nmol/L. AG14361 is at least 1000-fold more potent than the benzamides. The IC50 for AG14361 is 29 nM in permeabilized SW620 cells and 14 nM in intact SW620 cells.
