Avosentan
CAS 290815-26-8 MFCD90815268
化学结构图
SMILES: CC1C=CC(=NC=1)S(=O)(=O)NC1=NC(=NC(OC)=C1OC1=CC=CC=C1OC)C1C=CN=CC=1
化学属性
| Mol. Weight | 479.51 |
|---|---|
| Mol. Formula | C23H21N5O5S |
别名和识别编码
| CAS Number | 290815-26-8 |
|---|---|
| Chemical Name | Avosentan |
| Synonym | N-[6-Methoxy-5-(2-methoxyphenoxy)-2-(4-pyridinyl)-4-pyrimidinyl]-5-methyl-2-pyridinesulfonamide Ro 67-0565 SPP 301 |
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资金保障
专业采购外包团队在线服务
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现货库存
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分类
- Aromatics
- Heterocycles
- Inhibitors
- Pharmaceuticals
- Intermediates & Fine Chemicals
产品应用
- Avosentan is a competitive antagonist of Endothelin-1 (ET-1) with a high selectivity for the ETA receptor. Avosentan may be a potential option in the treatment of glaucoma.
相关文献及参考
- [2]. Konieczka K, Meyer P, Schoetzau A, Neutzner A, Mozaffarieh M, Flammer J.
- [3]. Mann JF, Green D, Jamerson K, Ruilope LM, Kuranoff SJ, Littke T, Viberti G; ASCEND Study Group.
- [4]. Dieterle W, Hengelage T.
- [5]. Effect of SPP 301, an Endothelin Antagonist, on Intraocular Pressure in Glaucomatous Monkey Eyes By Wang, Rong-Fang; Podos, Steven M.; Serle, Janet B.; Baltatu, Ovidiu C. From Current Eye Research (2011), 36(1), 41-46.
- Absolute bioavailability and pharmacokinetics of avosentan in man.
- Absolute bioavailability and pharmacokinetics of avosentan in man.
- Antidiuretic effects of the endothelin receptor antagonist avosentan.
- Antidiuretic effects of the endothelin receptor antagonist avosentan.
- Curr Eye Res. 2011 Feb;36(2):118-24.
- Curr Eye Res. 2011 Feb;36(2):118-24.
- Dieterle, W. et al.: J. Clin. Pharmacol., 44, 59 (2004); Dieterle, W. et al.: Int. J. Clin. Pharmacol. Ther., 43, 178 (2005); Wan
