OXi8007
CAS 288847-41-6 MFCD88847416
化学结构图
SMILES: COc1ccc2c(C(=O)c3cc(OC)c(OC)c(OC)c3)c(-c3ccc(OC)c(OP(=O)([O-])[O-])c3)[nH]c2c1.[Na+].[Na+]
化学属性
| Mol. Weight | 543.46 |
|---|---|
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | OXi8007 |
|---|---|
| Formula | C26H26NO10P |
| Synonym | OXi8007; OXi-8007; OXi 8007. |
| IUPAC Name | sodium 2-methoxy-5-(6-methoxy-3-(3,4,5-trimethoxybenzoyl)-1H-indol-2-yl)phenyl phosphate |
| InChIKey | GQIZTUAJGVBAFG-UHFFFAOYSA-L |
| InChI | InChI=1S/C26H26NO10P.2Na/c1-32-16-7-8-17-18(13-16)27-24(14-6-9-19(33-2)20(10-14)37-38(29,30)31)23(17)25(28)15-11-21(34-3)26(36-5)22(12-15)35-4;;/h6-13,27H,1-5H3,(H2,29,30,31);;/q;2*+1/p-2 |
| Canonical SMILES | O=P([O-])([O-])OC1=CC(C(N2)=C(C(C3=CC(OC)=C(OC)C(OC)=C3)=O)C4=C2C=C(OC)C=C4)=CC=C1OC.[Na+].[Na+] |
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产品应用
- OXi8007 is a vascular disrupting agent with potential anticancer activity. OXi8007 was found to be strongly cytotoxic against selected human cancer cell lines (GI50 = 36 nM against DU-145 cells, for example). OXi8007 also demonstrated pronounced interference with tumor vasculature in a preliminary in vivo study utilizing a SCID mouse model bearing an orthotopic PC-3 (prostate) tumor as imaged by color Doppler ultrasound. OXi8007 may be useful for the treatment of cancer.
