Isavuconazole 4-(2-((2R,3R)-3-(2,5-二氟苯基)-3-羟基-4-(1H-1,2,4-三唑-1-基)丁-2-基)噻唑-4-基)苯甲腈
CAS 241479-67-4 MFCD41479674
化学结构图
SMILES: C[C@@H](C1=NC(=CS1)C1C=CC(=CC=1)C#N)[C@](O)(CN1C=NC=N1)C1C=C(F)C=CC=1F |&1:1,15|
化学属性
| Mol. Weight | 437.47 |
|---|---|
| Mol. Formula | C22H17F2N5OS |
别名和识别编码
| CAS Number | 241479-67-4 |
|---|---|
| Chemical Name | Isavuconazole |
| Synonym | 4-[2-[(1R,2R)-2-(2,5-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazolyl]benzonitrile 2R,3R)-3-[4-(4-Cyanophenyl)thiazol-2-yl]-2-(2,5- |
| Chemical Name Translation | 4-(2-((2R,3R)-3-(2,5-二氟苯基)-3-羟基-4-(1H-1,2,4-三唑-1-基)丁-2-基)噻唑-4-基)苯甲腈 |
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分类
- Aromatics
- Chiral Reagents
- Heterocycles
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Sulfur & Selenium Compounds
产品应用
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相关文献及参考
- [2]. Steinmann J, et al. In Vitro Activity of Isavuconazole against Rasamsonia Species. Antimicrob Agents Chemother. 2016 Oct 21;60(11):6890-6891.
- [3]. Donnelley MA, et al. Isavuconazole in the treatment of invasive aspergillosis and mucormycosis infections. Infect Drug Resist. 2016 Jun 2;9:79-86.
- [4]. Box H, et al. Pharmacodynamics of Isavuconazole in a Dynamic In Vitro Model of Invasive Pulmonary Aspergillosis. Antimicrob Agents Chemother. 2015 Oct 26;60(1):278-87.
- [5]. Livermore J, et al. Evaluation of the pharmacokinetics and clinical utility of isavuconazole for treatment of invasive fungal infections. Expert Opin Drug Metab Toxicol. 2012 Jun;8(6):759-65.
- Ohwada, J., et al.: Bioorg. Med. Chem. Lett., 13, 191 (2003),
- [1]. Seifert H, et al. In vit
- [1]. Seifert H, et al. In vitro activities of isavuconazole and other antifungal agents against Candida bloodstream isolates. Antimicrob Agents Chemother. 2007 May;51(5):1818-21.
