Ritodrine Hydrochloride 利托君盐酸盐

CAS 23239-51-2 MFCD23239512

化学结构图

23239-51-2
SMILES: Cl.C[C@@H](NCCC1C=CC(O)=CC=1)[C@@H](O)C1C=CC(O)=CC=1 |&1:2,13|

化学属性

Mol. Weight323.85
Mol. FormulaC17H21NO3.ClH
Melting Point192-196 ºC

别名和识别编码

CAS Number23239-51-2
Chemical NameRitodrine Hydrochloride
Synonym N-[2-(p-Hydroxyphenyl)ethyl]-N-[2-(p-hydroxyphenyl)-2-hydroxy-1-methylethyl]amine Hydrochloride Pre-Par Du-21220 erythro-p-Hydroxy-alpha-(1-((p-hydroxyphenethyl)amino)ethyl)benzyl N-(p-Hydroxyphenylethyl)-4-hydroxynorephedrine Hydrochloride DU 21220 Prempar Miolene N-(p-Hydroxyphenethyl)-4-hydroxynorephedrine hydrochloride; (R*,S*)-4-Hydroxy-alpha-[1-[[2-(4-hydroxyphenyl)ethyl]amino]ethyl]benzyl alcohol hydrochloride
EC Number245-514-8
Wiswesser Line NotationQR DYQY1&M2R DQ &GH
Chemical Name Translation利托君盐酸盐
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Inhibitors,

产品应用

  • A ?2-Adrenergic agonist.

相关文献及参考

  • [2]. Medicinal Chemistry of Adrenergics and Cholinergics
  • Coutinho, et al.: Am. J. Obstet. Gynecol., 104, 1053 (1969),
  • Wesselius-De Casparis, et al.: Brit. Med. J., 3, 144 (1971),
  • [1]. Li, X., Y. Zhang, and Z. Shi, Ritodrine in the treatment of preterm labour: a meta-analysis. Indian J Med Res, 2005. 121(2): p. 120-7.
  • [1]. Li, X., Y. Zhang, and Z. Shi, Ritodrine in the treatment of preterm labour: a meta-analysis. Indian J Med Res, 2005. 121(2): p. 120-7.
  • [2]. Medicinal Chemistry of Adrenergics and Cholinergics

安全信息

Hazard Codes Xn
Safety Statements
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
RTECSDO6524000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kil

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 2458 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Behavioral - convulsions or effect on seizure threshold
   Cardiac - change in rate
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 18,5704,1984

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 330 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Liver - other changes
   Blood - changes in spleen
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 18,5704,1984

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 330 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure thres

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1840 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Behavioral - convulsions or effect on seizure threshold
   Gastrointestinal - other changes
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 18,5704,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 24 mg/kg
SEX/DURATION            : female 31-33 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - other effects
REFERENCE :
   GOBIDS Gynecologic and Obstetric Investigation.  (S. Karger Pub., Inc., 79
   Fif

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - woman
DOSE                    : 52 mg/kg
SEX/DURATION            : female 29-35 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - cardiovascular
   (circulatory) system
   Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
   AJOGAH American Journal of Obstetrics and Gynecology.  (C.V. Mosby Co.,
   11830 Westline Industrial Dr., St. Louis, MO 63146)  V.1-    1920-
   Volume(issue)/page/year: 149,798,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1050 mg/kg
SEX/DURATION            : female 10-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
   (e.

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - woman
DOSE                    : 450 ug/kg
SEX/DURATION            : female 39 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - Apgar score (human only)
   Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
   GOBIDS Gynecologic and Obstetric Investigation.  (S. Karger Pub., Inc., 79
   Fifth Ave., New York, NY 10003)  V.9-    1978-  Volume(issue)/page/year:
   23,160,1987

系列性分类

  1. Medical Research Areas
  2. GPCR & G Protein
  3. Adrenergic Receptor  (肾上腺素能受体)

相关产品推荐