BX471 (2R)-1-[[[4-氯-2-(脲基)苯氧基]甲基]羰基]-2-甲基-4-(4-氟苄基)哌嗪
CAS 217645-70-0 MFCD17645700
化学结构图
SMILES: C[C@@H]1CN(CCN1C(=O)COc1ccc(Cl)cc1NC(N)=O)Cc1ccc(F)cc1
化学属性
| Mol. Weight | 434.89 |
|---|---|
| Mol. Formula | C21H24ClFN4O3 |
别名和识别编码
| Synonym | N-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methyl-1-piperazinyl]-2-oxoethoxy]phenyl]-urea N-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methyl-1-piperazinyl]-2-oxoethoxy]phenyl]-urea ZK-811752 ZK-811752 |
|---|---|
| CAS Number | 217645-70-0 (free acid) |
| InChIKey | XQYASZNUFDVMFH-CQSZACIVSA-N |
| Chemical Name | BX471 |
| Chemical Name Translation | (2R)-1-[[[4-氯-2-(脲基)苯氧基]甲基]羰基]-2-甲基-4-(4-氟苄基)哌嗪 |
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信息真实价格透明
资金保障
专业采购外包团队在线服务
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分类
- {SA} Approved Therapeutics/Drug Candidates, B, Bayer, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Chemokine Inhibitors, Chemokines, Cytokines and Growth Factors, Cytokines, Growth Factors and Hormones
- {SNA} Approved Therapeutics/Drug Candidates, B, Bayer,
相关文献及参考
- [2]. Anders HJ, et al. A chemokine receptor CCR-1 antagonist reduces renal fibrosis after unilateral ureter ligation. J Clin Invest. 2002 Jan;109(2):251-9.
- [3]. Furuichi K, et al. Chemokine receptor CCR1 regulates inflammatory cell infiltration after renal ischemia-reperfusion injury. J Immunol. 2008 Dec 15;181(12):8670-6.
- [4]. Horuk R, et al. A non-peptide functional antagonist of the CCR1 chemokine receptor is effective in rat heart transplant rejection. J Biol Chem. 2001 Feb 9;276(6):4199-204.
- Furuichi K, Gao JL, Horuk R, Wada T, Kaneko S, Murphy PM., Chemokine receptor CCR1 regulates inflammatory cell infiltration after renal ischemia-reperfusion injury. J. Immunol. 12 , 8670-6, (2008)
- Horuk R, Clayberger C, Krensky AM, Wang Z, Grone HJ, Weber C, et al., A non-peptide functional antagonist of the CCR1 chemokine receptor is effective in rat heart transplant rejection. J. Biol. Chem. 6 , 4199-204, (2001)
- Liang M, Mallari C, Rosser M
安全信息
GHS Symbol
- P273 Avoid release to the environment. 避免释放到环境中。
- H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
- H302 Harmful if swallowed 吞食有害
- S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
- R50 Very toxic to aquatic organisms 对水生生物极毒
- R22 Harmful if swallowed 吞咽有害
