CL-387785 N-(4-((3-溴苯基)氨基)喹唑啉-6-基)丁-2-炔酰胺
CAS 194423-06-8 MFCD94423068
化学结构图
SMILES: CC#CC(=O)Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1
化学属性
| Mol. Formula | C18H13BrN4O |
|---|---|
| Mol. Weight | 381.23 |
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | CL-387785 |
|---|---|
| Chemical Name Translation | N-(4-((3-溴苯基)氨基)喹唑啉-6-基)丁-2-炔酰胺 |
| Chemicalbook ID | CB92626313 |
| Formula | C18H13BrN4O |
| Synonym | CL387785; CL 387785; CL-387785; EKI785; EK-I785; EK I785. |
| IUPAC Name | N-[4-[(3-Bromophenyl)amino]-6-quinazolinyl]-2-butynamide |
| InChIKey | BTYYWOYVBXILOJ-UHFFFAOYSA-N |
| InChI | InChI=1S/C18H13BrN4O/c1-2-4-17(24)22-14-7-8-16-15(10-14)18(21-11-20-16)23-13-6-3-5-12(19)9-13/h3,5-11H,1H3,(H,22,24)(H,20,21,23) |
| Canonical SMILES | CC#CC(NC1=CC2=C(NC3=CC=CC(Br)=C3)N=CN=C2C=C1)=O |
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产品应用
- CL-387785, also known as EKI-785 , is a n irreversible inhibitor of EGF-receptor (EGFR) kinase activity in vivo (IC50 = 250-490 pM). CL-387785 covalently bound to EGF-R. It also specifically inhibited kinase activity of the protein (IC50 = 370+/-120 pM), blocked EGF-stimulated autophosphorylation of the receptor in cells (ic50 approximately 5 nM), inhibited cell proliferation (IC50 = 31-125 nM) primarily in a cytostatic manner in cell lines that overexpress EGF-R or c-erbB-2, and profoundly blocked the growth of a tumor that overexpresses EGF-R in nude mice (when given orally at 80 mg/kg/day for 10 days, daily). CL-387,785 is useful for studying the interaction of small molecules with EGF-R and may have clinical utility.
