(6R,12Ar)-6-(Benzo[D][1,3]Dioxol-5-Yl)-2,3,6,7,12,12A-Hexahydropyrazino[1’,2’:1,6]Pyrido[3,4-b]Indole-1,4-Dione (6R,12aR)-6-(苯并[d][1,3]二氧杂环戊烯-5-基)-2,3,6,7,12,12a-六氢吡嗪并[1’,2’:1,6]吡啶并[3,4-b]吲哚-1,4-二酮
CAS 171596-36-4 MFCD71596364
化学结构图
SMILES:
化学属性
| Mol. Weight | 375.38 |
|---|---|
| Mol. Formula | C21H17N3O4 |
别名和识别编码
| CAS Number | 171596-36-4 |
|---|---|
| Chemical Name | (6R,12Ar)-6-(Benzo[D][1,3]Dioxol-5-Yl)-2,3,6,7,12,12A-Hexahydropyrazino[1’,2’:1,6]Pyrido[3,4-b]Indole-1,4-Dione |
| Synonym | (6R,12aR)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione (6R-trans)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b |
| Chemical Name Translation | (6R,12aR)-6-(苯并[d][1,3]二氧杂环戊烯-5-基)-2,3,6,7,12,12a-六氢吡嗪并[1’,2’:1,6]吡啶并[3,4-b]吲哚-1,4-二酮 |
| PubChem Substance ID | 9820973 |
| InChI | InChI=1S/C21H17N3O4/c25-18-9-22-21(26)15-8-13-12-3-1-2-4-14(12)23-19(13)20(24(15)18)11-5-6-16-17(7-11)28-10-27-16/h1-7,15,20,23H,8-10H2,(H,22,26)/t15-,20-/m1/s1 |
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分类
- Aromatics
- Drug Analogues
- Heterocycles
- Indole Derivatives
- Inhibitors
- Pharmaceuticals
- Intermediates & Fine Chemicals,
产品应用
- A N-desmethyl analogue of the human PDE5 inhibitor Tadalafil (T004500). A potential antiplasmodial drug.
相关文献及参考
- [2]. Daugan, et al. The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione analogue. Journal of Medicinal Chemistry (2003), 46(21), 4533-4542.
- [3]. Porst H, et al. Chronic PDE-5 inhibition in patients with erectile dysfunction - a treatment approach using tadalafil once-daily. Expert Opin Pharmacother. 2012 Jul;13(10):1481-94.
- [4]. Frey MK, Lang I. Tadalafil for the treatment of pulmonary arterial hypertension. Expert Opin Pharmacother. 2012 Apr;13(5):747-55.
- Beghyn, T. et al.: Bioorg. Med. Chem. Lett., 17, 789 (2007); Daugan, A. et al.: J. Med. Chem., 46, 4533 (2003);
- [1]. Beghyn, et al. PDE5 inhibitors: An original access to novel potent arylated analogues of tadalafil. Bioo
- [1]. Beghyn, et al. PDE5 inhibitors: An original access to novel potent arylated analogues of tadalafil. Bioorganic & Medicinal Chemistry Letters (2007), 17(3), 789-792.
