Salirasib 2-(((2E,6E)-3,7,11-三甲基十二碳-2,6,10-三烯-1-基)硫基)苯甲酸
CAS 162520-00-5 MFCD62520005
化学结构图
SMILES: CC(C)=CCC/C(/C)=C/CC/C(/C)=C/CSC1C=CC=CC=1C(O)=O
化学属性
| Mol. Weight | 359 |
|---|---|
| Mol. Formula | C22H30O2S |
别名和识别编码
| CAS Number | 162520-00-5 |
|---|---|
| Chemical Name | Salirasib |
| Synonym | 2-[[(2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrien-1-yl]thio]benzoic Acid |
| Chemical Name Translation | 2-(((2E,6E)-3,7,11-三甲基十二碳-2,6,10-三烯-1-基)硫基)苯甲酸 |
| MDL Number |
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信息真实价格透明
资金保障
专业采购外包团队在线服务
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现货库存
一流品牌服务
分类
- Aromatics
- Inhibitors
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Sulfur & Selenium Compounds
产品应用
- It is a new specific nontoxic drug with a mild hydrophobic nature, which acts as a Ras antagonist and can therefore be used for stent applications as well as for local cancer treatment.
相关文献及参考
- [2]. Nevo Y, et al. Chapman J. The Ras antagonist, farnesylthiosalicylic acid (FTS), decreases fibrosis and improves muscle strength in dy/dy mouse model of muscular dystrophy. PLoS One. 2011 Mar 22;6(3):e18049.
- [3]. Charette N, et al. Salirasib inhibits the growth of hepatocarcinoma cell lines in vitro and tumor growth in vivo through ras and mTOR inhibition. Mol Cancer. 2010 Sep 22;9:256.
- Marciano, D., et al.: J. Med. Chem., 38, 1267 (1995),
- [1]. Makovski V, et al. Farnesylthiosalicylic acid (salirasib) inhibits Rheb in TSC2-null ELT3 cells: a potential treatment for lymphangioleiomyomatosis. Int J Cancer. 2012 Mar 15;130(6):1420-9.
- [1]. Makovski V, et al. Farnesylthiosalicylic acid (salirasib) inhibits Rheb in TSC2-null ELT3 cells: a potential treatment for lymphangioleiomyomatosis. Int J Cancer. 2012 Mar 15;130(6):1420-9.
- [2]. Nevo Y, et al. Chapman J. The Ras antagonist, farnesylthiosalicylic acid (FTS), decreases fibrosis and
