(S)-N-((S)-6-amino-1-((2-amino-2-oxoethyl)amino)-1-oxohexan-2-yl)-1-((4R,7S,10S,13S,16S,19R)-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-19-(2-(2-(2-aminoacetamido)acetamido)acetamido)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5, 特利加压素
CAS 14636-12-5 MFCD14636125
化学结构图
SMILES: NCCCC[C@@H](NC(=O)[C@H]1CCCN1C(=O)[C@H]1CSSC[C@@H](NC(=O)CNC(=O)CNC(=O)CN)C(=O)N[C@H](CC2=CC=C(O)C=C2)C(=O)N[C@H](CC2C=CC=CC=2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O |&1:5,9,16,21,38,50,61,70|
化学属性
| Mol. Weight | 1227.37 |
|---|---|
| Mol. Formula | C52H74N16O15S2 |
别名和识别编码
| CAS Number | 14636-12-5 |
|---|---|
| Chemical Name | (S)-N-((S)-6-amino-1-((2-amino-2-oxoethyl)amino)-1-oxohexan-2-yl)-1-((4R,7S,10S,13S,16S,19R)-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-19-(2-(2-(2-aminoacetamido)acetamido)acetamido)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5, |
| Synonym | ######## N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin; (2S)-1-[(4S,7S,10S,13S,16S,19S)-19-[[2-[[2-[(2-Aminoacetyl)amino]acetyl]amino]acetyl]amino]-13-benzyl-10-(2-carbamoylethyl)-7-(carbamoylmethyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[(1S)-5-amino-1-(carbamoylmethylcarbamoyl)pentyl]pyrrolidine-2-carboxamide |
| EC Number | 238-680-8 |
| Chemical Name Translation | 特利加压素 |
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分类
- Amino Acids & Derivatives
- Peptides
- Pharmaceuticals
- Intermediates & Fine Chemicals,
产品应用
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相关文献及参考
- [2]. Yeun Tarl Fresner Ng Jao, et al. Refractory Torsade De Pointes Induced by Terlipressin (Glypressin). Int J Cardiol. 2016 Nov 1;222:135-140.
- [3]. Xiqiang Liu, et al. Signaling Through Hepatocyte Vasopressin Receptor 1 Protects Mouse Liver From Ischemia-Reperfusion Injury. Oncotarget. 2016 Oct 25;7(43):69276-69290.
- [4]. Xinmiao Zhou, et al. Terlipressin for the Treatment of Acute Variceal Bleeding: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Medicine (Baltimore). 2018 Nov;97(48):e13437.
- [5]. Alastair O'Brien, et al. Terlipressin for Norepinephrine-Resistant Septic Shock. Lancet. 2002 Apr 6;359(9313):1209-10.
- Uriz, J. et al.: J. Heptol., 33, 43 (2000); O'Brien, A. et al.: Lancet, 359, 1209 (2002); Burroughs, A.K. et al.: Digestion, 59, 26 (1998); Villanueva, C. et al.: Am. J. Gastroenterol., 100, 624 (2005
- [1]. Zi-Meng Liu, et al. Terlipressin Protects Intestinal Epithelial Cells Against Oxygen-Glucose De
