Lobaplatin 乐铂
CAS 135558-11-1 MFCD35558111
化学结构图
SMILES:
化学属性
| Mol. Formula | C9H18N2O3Pt |
|---|---|
| Mol. Weight | 397.33 |
别名和识别编码
| Chemical Name | Lobaplatin |
|---|---|
| Chemical Name Translation | 乐铂 |
| Chemicalbook ID | CB4741909 |
| Formula | C9H18N2O3Pt |
| Synonym | D19466; D-19466; Lobaplatin. |
| IUPAC Name | cis-[(1R*,2R*)-1,2-Cyclobutanebis(methylamino)-N,N'][(2S)-2-hydroxypropanoato(2-)-O1,O2]platinum |
| InChIKey | RLXPIABKJFUYFG-UHFFFAOYSA-M |
| InChI | InChI=1S/C6H14N2.C3H5O3.Pt/c7-3-5-1-2-6(5)4-8;1-2(4)3(5)6;/h5-6H,1-4,7-8H2;2H,1H3,(H,5,6);/q;-1;+2/p-1 |
| Canonical SMILES | CC([O-]1)C([O-][Pt]21[NH2+]CC(CC3)C3C[NH2+]2)=O. |
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产品应用
- Lobaplatin (D-19466) is a diastereometric mixture of platinum(II) complexes containing a 1,2-bis(aminomethyl)cyclobutane stable ligand and lactic acid as the leaving group. Its antitumour activity results from the formation of DNA-drug adducts, mainly as GG and AG intra-strand cross-links. Lobaplatin influences the expression of the c-myc gene, which is involved in oncogenesis, apoptosis and cell proliferation. Lobaplatin has activity in a wide range of preclinical tumour models and appears to overcome tumour resistance to cisplatin and carboplatin in some of these models. In the body, lobaplatin remains largely intact until removed by glomerular filtration. (source: Expert Opin Investig Drugs. 2001 Jan;10(1):119-28.).
