N-Hydroxy-2-(((2-(6-Methoxypyridin-3-Yl)-4-Morpholinothieno[3,2-D]Pyrimidin-6-Yl)Methyl)(Methyl)Amino)Pyrimidine-5-Carboxamide N-羟基-2-(((2-(6-甲氧基吡啶-3-基)-4-吗啉噻吩并[3,2-d]嘧啶-6-基)甲基)(甲基)氨基)嘧啶-5-甲酰胺
CAS 1339928-25-4 MFCD439928254
化学结构图
SMILES: COc1ccc(-c2nc(N3CCOCC3)c3sc(CN(C)c4ncc(C(=O)NO)cn4)cc3n2)cn1
化学属性
| Mol. Formula | C23H24N8O4S |
|---|---|
| Mol. Weight | 508.55 |
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | N-Hydroxy-2-(((2-(6-Methoxypyridin-3-Yl)-4-Morpholinothieno[3,2-D]Pyrimidin-6-Yl)Methyl)(Methyl)Amino)Pyrimidine-5-Carboxamide |
|---|---|
| Chemical Name Translation | N-羟基-2-(((2-(6-甲氧基吡啶-3-基)-4-吗啉噻吩并[3,2-d]嘧啶-6-基)甲基)(甲基)氨基)嘧啶-5-甲酰胺 |
| Chemicalbook ID | CB42645120 |
| Formula | C23H24N8O4S |
| Synonym | CUDC907; CUDC 907; CUDC-907; fimepinostat; |
| IUPAC Name | N-hydroxy-2-(((2-(6-methoxypyridin-3-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino)pyrimidine-5-carboxamide |
| InChIKey | JOWXJLIFIIOYMS-UHFFFAOYSA-N |
| InChI | InChI=1S/C23H24N8O4S/c1-30(23-25-11-15(12-26-23)22(32)29-33)13-16-9-17-19(36-16)21(31-5-7-35-8-6-31)28-20(27-17)14-3-4-18(34-2)24-10-14/h3-4,9-12,33H,5-8,13H2,1-2H3,(H,29,32) |
| Canonical SMILES | O=C(C1=CN=C(N(CC2=CC3=NC(C4=CC=C(OC)N=C4)=NC(N5CCOCC5)=C3S2)C)N=C1)NO |
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产品应用
- CUDC-907, also known as fimepinostat, is an orally bioavailable inhibitor of both phosphoinositide 3-kinase (PI3K) class I and pan histone deacetylase (HDAC) enzymes, with potential antineoplastic activity. Upon oral administration, CUDC-907 inhibits the activity of both PI3K class I isoforms and HDAC, thereby preventing the activation of the PI3K-AKT-mTOR signal transduction pathway that is often overactivated in many cancer cell types. This may prevent growth of PI3K and/or HDAC-expressing tumor cells. CUDC-907 shows an increased inhibition of tumor cell growth and induction of apoptosis when compared to inhibitors that target either PI3K or HDAC.
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