Darifenacin Hydrobromide 氢溴酸达非那新
CAS 133099-07-7 MFCD33099077
化学结构图
SMILES: Br.NC(=O)C([C@H]1CN(CC1)CCC1=CC2CCOC=2C=C1)(C1C=CC=CC=1)C1C=CC=CC=1
化学属性
| Mol. Weight | 507 |
|---|---|
| Mol. Formula | C28H30N2O2·HBr |
别名和识别编码
| CAS Number | 133099-07-7 |
|---|---|
| Chemical Name | Darifenacin Hydrobromide |
| Synonym | (3S)-1-[2-(2,3-Dihydro-5-benzofuranyl)ethyl]-?-?-diphenyl-3-pyrrolidineacetamide Hydrobromide Enablex Emselex |
| Chemical Name Translation | 氢溴酸达非那新 |
| MDL Number | N/A |
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信息真实价格透明
资金保障
专业采购外包团队在线服务
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现货库存
一流品牌服务
分类
- Amines
- Aromatics
- Heterocycles
- Pharmaceuticals
- Intermediates & Fine Chemicals
产品应用
- Used as a medication to treat urinary incontinence. It works by blocking the M3 muscarinic acetylcholine receptor.
相关文献及参考
- [2]. Miller DW, et al. Evaluation of drug efflux transporter liabilities of darifenacin in cell culture models of the blood-brain and blood-ocular barriers. Neurourol Urodyn, 2011, 30(8), 1633-1638.
- [3]. Iijima K, et al. Effects of the M3 receptor selective muscarinic antagonist darifenacin on bladder afferent activity of the rat pelvic nerve. Eur Urol, 2007, 52(3), 842-847.
- Beaumont, K.C., et al.: Xenobiotica, 28, 63 (1998),
- Chapple, C.R., et al.: Expert Opin. Invest. Drugs, 13, 1493 (2004),
- Haab, F., et al.: Eur. Urol., 45, 420 (2004),
- [1]. Hegde SS, et al. Functional role of M2 and M3 muscarinic receptors in the urinary bladder of rats in vitro and in vivo. Br J Pharmacol, 1997, 120(8), 1409-1418.
- [1]. Hegde SS, et al. Functional role of M2 and M3 muscarinic receptors in the urinary bladder of rats in vitro and in vivo. Br J Pharmacol, 1997, 120(8), 1409-1418.
- [2]. Miller DW, et al. Evaluation of drug efflux transporter
安全信息
GHS Symbol
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P273 Avoid release to the environment. 避免释放到环境中。
- P301+P312
- P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
