(5-Amino-1-(2-Methyl-1H-Benzo[D]Imidazol-6-Yl)-1H-Pyrazol-4-Yl)(1H-Indol-2-Yl)Methanone (5-氨基-1-(2-甲基-1H-苯并[d]咪唑-6-基)-1H-吡唑-4-基)(1H-吲哚-2-基)甲酮
CAS 1265229-25-1 MFCD365229251
化学结构图
SMILES:
化学属性
| Mol. Weight | 356.38 |
|---|---|
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name Translation | (5-氨基-1-(2-甲基-1H-苯并[d]咪唑-6-基)-1H-吡唑-4-基)(1H-吲哚-2-基)甲酮 |
|---|---|
| Chemical Name | (5-Amino-1-(2-Methyl-1H-Benzo[D]Imidazol-6-Yl)-1H-Pyrazol-4-Yl)(1H-Indol-2-Yl)Methanone |
| Formula | C20H16N6O |
| Synonym | Debio-1347; Debio 1347; Debio1347; CH5183284; CH 5183284; CH-5183284; FF284; FF-284; FF 284. |
| IUPAC Name | (5-amino-1-(2-methyl-1H-benzo[d]imidazol-6-yl)-1H-pyrazol-4-yl)(1H-indol-2-yl)methanone |
| InChIKey | BEMNJULZEQTDJY-UHFFFAOYSA-N |
| InChI | InChI=1S/C20H16N6O/c1-11-23-16-7-6-13(9-17(16)24-11)26-20(21)14(10-22-26)19(27)18-8-12-4-2-3-5-15(12)25-18/h2-10,25H,21H2,1H3,(H,23,24) |
信息真实价格透明
资金保障
专业采购外包团队在线服务
信息真实价格透明
资金保障
专业采购外包团队在线服务
品牌质保精细包装
现货库存
一流品牌服务
产品应用
- Debio-1347, also known as FF284 and CH5183284, is an orally bioavailable inhibitor of the fibroblast growth factor receptor subtypes 1 (FGFR-1), 2 (FGFR-2) and 3 (FGFR-3), with potential antineoplastic activity. FGFR inhibitor debio 1347 binds to and inhibits FGFR-1, -2, and -3, which result in the inhibition of FGFR-mediated signal transduction pathways. This leads to the inhibition of both tumor cell proliferation and angiogenesis, and causes cell death in FGFR-overexpressing tumor cells.
