N-(2-Aminophenyl)-6-[(7-methoxy-4-quinolinyl)oxy]-1-naphthalenecarboxamide N-(2-氨基苯基)-6-[(7-甲氧基-4-喹啉基)氧基]-1-萘甲酰胺
CAS 1256349-48-0 MFCD356349480
化学结构图
SMILES: COc1ccc2c(Oc3ccc4c(C(=O)Nc5ccccc5N)cccc4c3)ccnc2c1
化学属性
| Mol. Weight | 435.483 |
|---|---|
| Appearance | white solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | N-(2-Aminophenyl)-6-[(7-methoxy-4-quinolinyl)oxy]-1-naphthalenecarboxamide |
|---|---|
| Formula | C27H21N3O3 |
| Synonym | Chiauranib; CS2164; CS-2164; CS 2164. |
| IUPAC Name | N-(2-aminophenyl)-6-((7-methoxyquinolin-4-yl)oxy)-1-naphthamide |
| InChIKey | BRKWREZNORONDU-UHFFFAOYSA-N |
| InChI | InChI=1S/C27H21N3O3/c1-32-18-9-12-22-25(16-18)29-14-13-26(22)33-19-10-11-20-17(15-19)5-4-6-21(20)27(31)30-24-8-3-2-7-23(24)28/h2-16H,28H2,1H3,(H,30,31) |
| Canonical SMILES | O=C(C1=C2C=CC(OC3=CC=NC4=CC(OC)=CC=C43)=CC2=CC=C1)NC5=CC=CC=C5N |
| Chemical Name Translation | N-(2-氨基苯基)-6-[(7-甲氧基-4-喹啉基)氧基]-1-萘甲酰胺 |
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产品应用
- Chiauranib also known as orally available, small molecule inhibitor of select serine-threonine kinases, including aurora kinase B (aurora B), vascular endothelial growth factor receptors (VEGFRs), stem cell factor receptor (c-KIT), and platelet-derived growth factor receptors (PDGFRs), with potential antineoplastic activity. Upon oral administration, chiauranib binds to and inhibits the activity of aurora B, VEGFRs, c-kit and PDGFRs, which may result in a decrease in the proliferation of tumor cells that overexpress these kinases. These kinases are overexpressed by a variety of cancer cell types.
