1-(5-((2,4-difluorophenyl)thio)-4-nitrothiophen-2-yl)ethan-1-one 1-(5-((2,4-二氟苯基)硫基)-4-硝基噻吩-2-基)乙酮
CAS 1247819-59-5 MFCD347819595
化学结构图
SMILES: CC(=O)c1cc([N+](=O)[O-])c(Sc2ccc(F)cc2F)s1
化学属性
| Mol. Weight | 315.31 |
|---|---|
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name Translation | 1-(5-((2,4-二氟苯基)硫基)-4-硝基噻吩-2-基)乙酮 |
|---|---|
| Chemical Name | 1-(5-((2,4-difluorophenyl)thio)-4-nitrothiophen-2-yl)ethan-1-one |
| Formula | C12H7F2NO3S2 |
| Synonym | P22077; P-22077; P 22077. |
| IUPAC Name | 1-(5-((2,4-difluorophenyl)thio)-4-nitrothiophen-2-yl)ethanone |
| InChIKey | RMAMGGNACJHXHO-UHFFFAOYSA-N |
| InChI | InChI=1S/C12H7F2NO3S2/c1-6(16)11-5-9(15(17)18)12(20-11)19-10-3-2-7(13)4-8(10)14/h2-5H,1H3 |
| Canonical SMILES | CC(C1=CC([N+]([O-])=O)=C(SC2=CC=C(F)C=C2F)S1)=O |
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产品应用
- P22077 is a potent and selective ubiquitin-specific protease 7 (USP7) inhibitor. P22077 potently induces apoptosis in NB cells with an intact USP7-HDM2-p53 axis but not in NB cells with mutant p53 or without human homolog of MDM2 (HDM2) expression. P22077 also significantly augmented the cytotoxic effects of doxorubicin (Dox) and etoposide (VP-16) in NB cells with an intact USP7-HDM2-p53 axis. Moreover, P22077 was found to be able to sensitize chemoresistant LA-N-6 NB cells to chemotherapy. In an in vivo orthotopic NB mouse model, P22077 significantly inhibited the xenograft growth of three NB cell lines. USP7-specific inhibitors like P22077 may serve not only as a stand-alone therapy but also as an effective adjunct to current chemotherapeutic regimens for treating NB with an intact USP7-HDM2-p53 axis.
