3-(4-(2-((6-Amino-9-((2R,3R,4S,5S)-5-(Ethylcarbamoyl)-3,4-Dihydroxytetrahydrofuran-2-Yl)-9H-Purin-2-Yl)Amino)Ethyl)Phenyl)Propanoic Acid Hydrochloride 3-(4-(2-((6-氨基-9-((2R,3R,4S,5S)-5-(乙基氨基甲酰基)-3,4-二羟基四氢呋喃-2-基)-9H-嘌呤-2-基)氨基)乙基)苯基)丙酸盐酸盐
CAS 124431-80-7 MFCD24431807
化学结构图
SMILES: [3H]C([3H])(C1C=CC(CCNC2=NC3=C(N=CN3[C@@H]3O[C@@H]([C@@H](O)[C@H]3O)C(=O)NCC)C(N)=N2)=CC=1)C([3H])([3H])C(O)=O
化学属性
| Mol. Weight | 535.98 |
|---|---|
| Mol. Formula | C23H30ClN7O6 |
别名和识别编码
| CAS Number | 124431-80-7 |
|---|---|
| Chemical Name | 3-(4-(2-((6-Amino-9-((2R,3R,4S,5S)-5-(Ethylcarbamoyl)-3,4-Dihydroxytetrahydrofuran-2-Yl)-9H-Purin-2-Yl)Amino)Ethyl)Phenyl)Propanoic Acid Hydrochloride |
| Synonym | CGS 21680 Hydrochloride 4-[2-[[6-Amino-9-(N-ethyl-?-D-ribofuranuronamidosyl)-9H-purin-2-yl]amino]ethyl]benzenepropanoic Acid Hydrochloride |
| Chemical Name Translation | 3-(4-(2-((6-氨基-9-((2R,3R,4S,5S)-5-(乙基氨基甲酰基)-3,4-二羟基四氢呋喃-2-基)-9H-嘌呤-2-基)氨基)乙基)苯基)丙酸盐酸盐 |
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分类
- Carbohydrates & Derivatives
- Chiral Reagents
- Pharmaceuticals
- Intermediates & Fine Chemicals
产品应用
- A selective A2A receptor agonist.
相关文献及参考
- [2]. Komaki S, et al. Trk and cAMP-dependent survival activity of adenosine A(2A) agonist CGS21680 on rat motoneurons in culture. Neurosci Lett. 2012 Jul 26;522(1):21-4.
- [3]. Zhang M, et al. Activation of the adenosine A2A receptor exacerbates experimental autoimmune neuritis in Lewis rats in association with enhanced humoral immunity. J Neuroimmunol. 2016 Apr 15;293:129-36.
- [4]. Rosaria Volpini, et al. Adenosine receptor agonists: synthesis and binding affinity of 2-(aryl)alkylthioadenosine derivatives.
- [5]. Melani A, et al. Low doses of the selective adenosine A2A receptor agonist CGS21680 are protective in a rat model of transient cerebral ischemia. Brain Res. 2014 Mar 10;1551:59-72.
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- [1]. Bao
- [1]. Bao R, et al. Adenosine and the adenosine A2A receptor agonist, CGS21680, upregulate CD39 and CD73 expression through E2F-1 and CREB in regulatory T cells isolated from septic mice. Int J Mol Med. 2016 Sep;38(3):969-75.
