(R)-6-(2-Fluorophenyl)-N-(3-(2-((2-Methoxyethyl)Amino)Ethyl)Phenyl)-5,6-Dihydrobenzo[H]Quinazolin-2-Amine (R)-6-(2-氟苯基)-N-(3-(2-((2-甲氧基乙基)氨基)乙基)苯基)-5,6-二氢苯并[h]喹唑啉-2-胺
CAS 1234356-69-4 MFCD334356694
化学结构图
SMILES: COCCNCCc1cccc(Nc2ncc3c(n2)-c2ccccc2[C@H](c2ccccc2F)C3)c1
化学属性
| Mol. Weight | 468.5764 |
|---|---|
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name Translation | (R)-6-(2-氟苯基)-N-(3-(2-((2-甲氧基乙基)氨基)乙基)苯基)-5,6-二氢苯并[h]喹唑啉-2-胺 |
|---|---|
| Chemical Name | (R)-6-(2-Fluorophenyl)-N-(3-(2-((2-Methoxyethyl)Amino)Ethyl)Phenyl)-5,6-Dihydrobenzo[H]Quinazolin-2-Amine |
| Formula | C29H29FN4O |
| Synonym | ARQ 087; ARQ087; ARQ-087; Derazantinib |
| IUPAC Name | (6R)-6-(2-fluorophenyl)-N-(3-{2-[(2-methoxyethyl)amino]ethyl}phenyl)-5,6-dihydrobenzo[h]quinazolin-2-amine |
| InChIKey | KPJDVVCDVBFRMU-AREMUKBSSA-N |
| InChI | InChI=1S/C29H29FN4O/c1-35-16-15-31-14-13-20-7-6-8-22(17-20)33-29-32-19-21-18-26(24-10-4-5-12-27(24)30)23-9-2-3-11-25(23)28(21)34-29/h2-12,17,19,26,31H,13-16,18H2,1H3,(H,32,33,34)/t26-/m1/s1 |
| Canonical SMILES | COCCNCCC1=CC(NC2=NC=C3C[C@@H](C4=CC=CC=C4F)C5=CC=CC=C5C3=N2)=CC=C1 |
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产品应用
- Derazantinib, also known as ARQ-087, is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) with potential antineoplastic activity. FGFR inhibitor ARQ 087 binds to and potently inhibits the activity of FGFR subtypes 1, 2 and 3. This may result in the inhibition of FGFR-mediated signal transduction pathways, tumor cell proliferation, tumor angiogenesis and tumor cell death in FGFR-overexpressing tumor cells. FGFR, a receptor tyrosine kinase, is upregulated in many tumor cell types and plays a key role in tumor cellular proliferation, differentiation, angiogenesis and survival.
