6-(1H-Indazol-6-Yl)-N-(4-Morpholinophenyl)Imidazo[1,2-a]Pyrazin-8-Amine 6-(1H-吲唑-6-基)-N-[4-(4-吗啉基)苯基]咪唑并[1,2-a]吡嗪-8-胺
CAS 1229208-44-9 MFCD329208449
化学结构图
SMILES: c1cn2cc(-c3ccc4cn[nH]c4c3)nc(Nc3ccc(N4CCOCC4)cc3)c2n1
化学属性
| Mol. Weight | 411.46 |
|---|---|
| Appearance | white solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name Translation | 6-(1H-吲唑-6-基)-N-[4-(4-吗啉基)苯基]咪唑并[1,2-a]吡嗪-8-胺 |
|---|---|
| Chemical Name | 6-(1H-Indazol-6-Yl)-N-(4-Morpholinophenyl)Imidazo[1,2-a]Pyrazin-8-Amine |
| Formula | C23H21N7O |
| Synonym | Entospletinib; GS9973; GS 9973; GS-9973. |
| IUPAC Name | 6-(1H-indazol-6-yl)-N-(4-morpholinophenyl)imidazo[1,2-a]pyrazin-8-amine |
| InChIKey | XSMSNFMDVXXHGJ-UHFFFAOYSA-N |
| InChI | InChI=1S/C23H21N7O/c1-2-17-14-25-28-20(17)13-16(1)21-15-30-8-7-24-23(30)22(27-21)26-18-3-5-19(6-4-18)29-9-11-31-12-10-29/h1-8,13-15H,9-12H2,(H,25,28)(H,26,27) |
| Canonical SMILES | C12=NC=CN1C=C(C3=CC4=C(C=C3)C=NN4)N=C2NC5=CC=C(N6CCOCC6)C=C5 |
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产品应用
- Entospletinib, also known as GS-9973, is a highly selective and orally efficacious Syk inhibitor which is currently undergoing clinical evaluation for autoimmune and oncology indications. In Phase II clinical trials, Entospletinib demonstrates clinical activity in subjects with relapsed or refractory CLL with acceptable toxicity.
