(E)-5-((5-(4-Fluorophenyl)furan-2-yl)methylene)thiazolidine-2,4-dione (E)-5-((5-(4-氟苯基)呋喃-2-基)亚甲基)噻唑烷-2,4-二酮
CAS 1218777-13-9 MFCD318777139
化学结构图
SMILES: O=C1NC(=O)/C(=C\c2ccc(-c3ccc(F)cc3)o2)S1
化学属性
| Mol. Weight | 289.28 |
|---|---|
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not soluble in water or ethanol. |
别名和识别编码
| Chemical Name Translation | (E)-5-((5-(4-氟苯基)呋喃-2-基)亚甲基)噻唑烷-2,4-二酮 |
|---|---|
| Chemical Name | (E)-5-((5-(4-Fluorophenyl)furan-2-yl)methylene)thiazolidine-2,4-dione |
| Formula | C14H8FNO3S |
| Synonym | CAY10505; CAY 10505; CAY10505 |
| IUPAC Name | (E)-5-((5-(4-fluorophenyl)furan-2-yl)methylene)thiazolidine-2,4-dione |
| InChIKey | UFBTYTGRUBUUIL-KPKJPENVSA-N |
| InChI | InChI=1S/C14H8FNO3S/c15-9-3-1-8(2-4-9)11-6-5-10(19-11)7-12-13(17)16-14(18)20-12/h1-7H,(H,16,17,18)/b12-7+ |
| Canonical SMILES | O=C(NC/1=O)SC1=C\C2=CC=C(C3=CC=C(F)C=C3)O2 |
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产品应用
- CAY10505 is a phosphatidylinositol 3-kinase-γ inhibitor , was found to significantly improve acetylcholine-induced endothelium dependent relaxation, serum nitrate and (or) nitrite level, glutathione level, and the vascular endothelial lining in hypertensive rats. CAY10505 , may improve hypertension-associated vascular endothelial dysfunction. Inhibition of PI3Kγ might be a useful approach in the therapeutics of vascular endothelium dysfunction.
