4-(4-((4-((3-Acrylamidophenyl)Amino)-5-Fluoropyrimidin-2-Yl)Amino)Phenoxy)-N-Methylpicolinamide 4-(4-((4-((3-丙烯酰胺苯基)氨基)-5-氟嘧啶-2-基)氨基)苯氧基)-N-甲基吡啶酰胺
CAS 1202759-32-7 MFCD302759327
化学结构图
SMILES: C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(Oc4ccnc(C(=O)NC)c4)cc3)ncc2F)c1
化学属性
| Mol. Weight | 499.49638 |
|---|---|
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name Translation | 4-(4-((4-((3-丙烯酰胺苯基)氨基)-5-氟嘧啶-2-基)氨基)苯氧基)-N-甲基吡啶酰胺 |
|---|---|
| Chemical Name | 4-(4-((4-((3-Acrylamidophenyl)Amino)-5-Fluoropyrimidin-2-Yl)Amino)Phenoxy)-N-Methylpicolinamide |
| Formula | C26H22FN7O3 |
| Synonym | CNX774; CNX 774; CNX-774. |
| IUPAC Name | 4-(4-((4-((3-acrylamidophenyl)amino)-5-fluoropyrimidin-2-yl)amino)phenoxy)-N-methylpicolinamide |
| InChIKey | VVLHQJDAUIPZFH-UHFFFAOYSA-N |
| InChI | InChI=1S/C26H22FN7O3/c1-3-23(35)31-17-5-4-6-18(13-17)32-24-21(27)15-30-26(34-24)33-16-7-9-19(10-8-16)37-20-11-12-29-22(14-20)25(36)28-2/h3-15H,1H2,2H3,(H,28,36)(H,31,35)(H2,30,32,33,34) |
| Canonical SMILES | O=C(NC)C1=NC=CC(OC2=CC=C(NC3=NC=C(F)C(NC4=CC=CC(NC(C=C)=O)=C4)=N3)C=C2)=C1 |
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产品应用
- CNX-774 is a potent Btk inhibitor (IC50 < 1 nM). Recently Bruton's tyrosine kinase (BTK) , a crucial terminal kinase enzyme in the B-cell antigen receptor (BCR) signaling pathway, has emerged as an attractive target for therapeutic intervention in human malignancies and autoimmune disorders.
