(R)-6-(1-(8-Fluoro-6-(1-Methyl-1H-Pyrazol-4-Yl)-[1,2,4]Triazolo[4,3-A]Pyridin-3-Yl)Ethyl)-3-(2-Methoxyethoxy)-1,6-Naphthyridin-5(6H)-One (R)-6-(1-(8-氟-6-(1-甲基-1H-吡唑-4-基)-[1,2,4]三唑并[4,3-a]吡啶-3-基)乙基)-3-(2-甲氧基乙氧基)-1,6-萘啶-5(6H)-酮
CAS 1173699-31-4 MFCD273699314
化学结构图
SMILES: COCCOc1cnc2ccn([C@H](C)c3nnc4c(F)cc(-c5cnn(C)c5)cn34)c(=O)c2c1
化学属性
| Mol. Weight | 463.4734 |
|---|---|
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | (R)-6-(1-(8-Fluoro-6-(1-Methyl-1H-Pyrazol-4-Yl)-[1,2,4]Triazolo[4,3-A]Pyridin-3-Yl)Ethyl)-3-(2-Methoxyethoxy)-1,6-Naphthyridin-5(6H)-One |
|---|---|
| Formula | C23H22FN7O3 |
| Synonym | AMG337; AMG-337; AMG 337. |
| IUPAC Name | (R)-6-(1-(8-fluoro-6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)ethyl)-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)-one |
| InChIKey | DWHXUGDWKAIASB-CQSZACIVSA-N |
| InChI | InChI=1S/C23H22FN7O3/c1-14(30-5-4-20-18(23(30)32)9-17(11-25-20)34-7-6-33-3)21-27-28-22-19(24)8-15(13-31(21)22)16-10-26-29(2)12-16/h4-5,8-14H,6-7H2,1-3H3/t14-/m1/s1 |
| Canonical SMILES | O=C1C2=C(N=CC(OCCOC)=C2)C=CN1[C@@H](C3=NN=C4C(F)=CC(C5=CN(C)N=C5)=CN43)C |
| Chemical Name Translation | (R)-6-(1-(8-氟-6-(1-甲基-1H-吡唑-4-基)-[1,2,4]三唑并[4,3-a]吡啶-3-基)乙基)-3-(2-甲氧基乙氧基)-1,6-萘啶-5(6H)-酮 |
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产品应用
- AMG 337 is an orally bioavailable inhibitor of the proto-oncogene c-Met with potential antineoplastic activity. c-Met inhibitor AMG 337 selectively binds to c-Met, thereby disrupting c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein.
