G-479 is an potent MEK inhibitor. Structurally, G-479 is an analogue of GDC-0623 (or so-call Me-Too drug). G-479 with polarity distributed throughout the molecule was shown improved bioactivity over GDC-0623 in many aspects.
CAS 1168092-22-5 MFCD268092225
化学结构图
SMILES: O=C(NOC[C@H](O)CO)c1ncc2cncn2c1Nc1ccc(I)cc1F
化学属性
| Mol. Weight | 487.22 |
|---|---|
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | G-479 is an potent MEK inhibitor. Structurally, G-479 is an analogue of GDC-0623 (or so-call Me-Too drug). G-479 with polarity distributed throughout the molecule was shown improved bioactivity over GDC-0623 in many aspects. |
|---|---|
| Formula | C16H15FIN5O4 |
| Synonym | G479; G-479; G 479. |
| IUPAC Name | (R)-N-(2,3-dihydroxypropoxy)-5-((2-fluoro-4-iodophenyl)amino)imidazo[1,5-a]pyrazine-6-carboxamide |
| InChIKey | OKOKEHVACWMOFN-LLVKDONJSA-N |
| InChI | InChI=1S/C16H15FIN5O4/c17-12-3-9(18)1-2-13(12)21-15-14(16(26)22-27-7-11(25)6-24)20-5-10-4-19-8-23(10)15/h1-5,8,11,21,24-25H,6-7H2,(H,22,26)/t11-/m1/s1 |
| Canonical SMILES | O=C(C1=C(NC2=CC=C(I)C=C2F)N3C(C=N1)=CN=C3)NOC[C@H](O)CO |
信息真实价格透明
资金保障
专业采购外包团队在线服务
信息真实价格透明
资金保障
专业采购外包团队在线服务
品牌质保精细包装
现货库存
一流品牌服务
产品应用
- G-479 is an potent MEK inhibitor. Structurally, G-479 is an analogue of GDC-0623 (or so-call Me-Too drug). G-479 with polarity distributed throughout the molecule was shown improved bioactivity over GDC-0623 in many aspects.
