Molidustat Bay85-3934 消毒剂BAY-85-934
CAS 1154028-82-6 MFCD254028826
化学结构图
SMILES: O=c1c(-n2ccnn2)c[nH]n1-c1cc(N2CCOCC2)ncn1
化学属性
| Mol. Weight | 314.3 |
|---|---|
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name Translation | 消毒剂BAY-85-934 |
|---|---|
| Chemical Name | Molidustat Bay85-3934 |
| Formula | C13H14N8O2 |
| Synonym | BAY 85-3934; BAY-85-3934; BAY85-3934; BAY 853934; BAY-853934; BAY853934; Molidustat. |
| IUPAC Name | 2-(6-morpholinopyrimidin-4-yl)-4-(1H-1,2,3-triazol-1-yl)-1H-pyrazol-3(2H)-one |
| InChIKey | IJMBOKOTALXLKS-UHFFFAOYSA-N |
| InChI | InChI=1S/C13H14N8O2/c22-13-10(20-2-1-16-18-20)8-17-21(13)12-7-11(14-9-15-12)19-3-5-23-6-4-19/h1-2,7-9,17H,3-6H2 |
| Canonical SMILES | O=C1N(C2=NC=NC(N3CCOCC3)=C2)NC=C1N4N=NC=C4 |
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产品应用
- Molidustat, also known as BAY 85-3934, is a novel inhibitor of hypoxia-inducible factor (HIF) prolyl hydroxylase (PH) which stimulates erythropoietin (EPO) production and the formation of red blood cells. Phase I data have shown that inhibition of HIF-PH by Molidustat results in an increase in endogenous production of EPO. Molidustat is currently clinical trials at Bayer for the treatment of patients suffering from renal anemia due to chronic kidney disease.
