8-Hydroxy-3-Methyl-3,4-Dihydrotetraphene-1,7,12(2H)-Trione 8-羟基-3-甲基-3,4-二氢苯并蒽-1,7,12(2H)-三酮
CAS 111540-00-2 MFCD11540002
化学结构图
SMILES: CC1CC(=O)c2c(ccc3c2C(=O)c2cccc(O)c2C3=O)C1
化学属性
| Mol. Weight | 306.31 |
|---|---|
| Appearance | white solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name Translation | 8-羟基-3-甲基-3,4-二氢苯并蒽-1,7,12(2H)-三酮 |
|---|---|
| PubChem Substance ID | 363709 |
| InChI | InChI=1S/C19H14O4/c1-9-7-10-5-6-12-17(15(10)14(21)8-9)19(23)11-3-2-4-13(20)16(11)18(12)22/h2-6,9,20H,7-8H2,1H3 |
| Synonym | STA-21 STA21; STA 21; STA21; Ochromycinone; NSC 628869. |
| InChIKey | ZAWXOCUFQSQDJS-UHFFFAOYSA-N |
| Chemical Name | 8-Hydroxy-3-Methyl-3,4-Dihydrotetraphene-1,7,12(2H)-Trione |
| Formula | C19H14O4 |
| IUPAC Name | 8-hydroxy-3-methyl-3,4-dihydrotetraphene-1,7,12(2H)-trione |
| Canonical SMILES | O=C1CC(C)CC2=CC=C3C(C(C4=CC=CC(O)=C4C3=O)=O)=C12 |
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产品应用
- STA-21 is a promising STAT-3 inhibitor that reciprocally regulates Th17 and Treg cells, inhibits osteoclastogenesis in mice and humans and alleviates autoimmune inflammation in an experimental model of rheumatoid arthritis. STA-21 improved the clinical course of arthritis in IL-1Ra-KO mice. It increased not only the number of Treg cells but also the function of the Treg cells. It also suppressed Th17 cells and osteoclast formation. These data suggest that STA-21 might be an effective treatment for patients with RA.
