CH5164840
CAS 1052645-73-4 MFCD152645734
化学结构图
SMILES: Cc1cc(C)c2cc1C(=O)NCCCNC(=O)CCSc1cc-2nc(N)n1
化学属性
| Mol. Weight | 385.48322 |
|---|---|
| Appearance | white solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | CH5164840 |
|---|---|
| Formula | C19H23N5O2S |
| Synonym | CH5164840; CH-5164840; CH 5164840. |
| IUPAC Name | 7 -Thia-3,5,11,15-tetraazatricyclo[15.3.1.12,6]docosa-1(21),2,4,6(22),17,19-hexaene-10,16-dione, 4-amino-18,20-dimethyl-. |
| InChIKey | OMFBVBRFVYLRQT-UHFFFAOYSA-N |
| InChI | InChI=1S/C19H23N5O2S/c1-11-8-12(2)14-9-13(11)15-10-17(24-19(20)23-15)27-7-4-16(25)21-5-3-6-22-18(14)26/h8-10H,3-7H2,1-2H3,(H,21,25)(H,22,26)(H2,20,23,24) |
| Canonical SMILES | NC1=NC(C(C=C2C(NCCCN3)=O)=C(C)C=C2C)=CC(SCCC3=O)=N1 |
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产品应用
- CH5164840 is a potent and selective HSP90 inhibitor. CH5164840 showed remarkable antitumor activity against NSCLC cell lines and xenograft models. CH5164840 has potent antitumor activity and is highly effective in combination with erlotinib against NSCLC tumors with EGFR overexpression and mutations.
