(R)-Pramipexole Dihydrochloride 普拉克索杂质E

CAS 104632-28-2 MFCD04632282

化学结构图

104632-28-2
SMILES: CCCN[C@H]1CC2SC(N)=NC=2CC1

化学属性

Mol. Weight284.25
Mol. FormulaC10H19Cl2N3S

别名和识别编码

CAS Number104632-28-2
Chemical Name(R)-Pramipexole Dihydrochloride
Synonym (R)-4,5,6,7-Tetrahydro-N6-propyl-2,6-benzothiazolediamine Dihydrochloride R-(+)-Pramipexole Dihydrochloride
Chemical Name Translation普拉克索杂质E
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分类

  • Chiral Reagents
  • Inhibitors
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Sulfur & Selenium Compounds

产品应用

  • The opposite enantiomer of Pramipexole (P700755),

相关文献及参考

  • [2]. Alavian KN, Dworetzky SI, Bonanni L, et al. Effects of dexpramipexole on brain mitochondrial conductances and cellular bioenergetic efficiency. Brain Res. 2012 Mar 29;1446:1-11.
  • [3]. Cudkowicz M, Bozik ME, Ingersoll EW, et al. The effects of dexpramipexole (KNS-760704) in individuals with amyotrophic lateral sclerosis. Nat Med. 2011 Nov 20;17(12):1652-6.
  • [4]. Bozik ME, Mather JL, Kramer WG, et al. Safety, tolerability, and pharmacokinetics of KNS-760704 (dexpramipexole) in healthy adult subjects. J Clin Pharmacol. 2011 Aug;51(8):1177-85.
  • [5]. Cheah BC, Kiernan MC. Dexpramipexole, the R(+) enantiomer of pramipexole, for the potential treatment of amyotrophic lateral sclerosis. IDrugs. 2010 Dec;13(12):911-20.
  • Mierau, J., et al.: J. Med. Chem., 30, 494 (1987),
  • Schilling, J.C., et al.: Clin. Pharmacol. Ther., 51, 541 (1992),
  • [1]. Rudnicki SA, Berry JD, Ingersoll E, et al. Dexpramipexole effects on functional decline and survi

系列性分类


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