7-[[4-(3-Ethynylphenylamino)-7-Methoxyquinazolin-6-Yl]Oxy]-N-Hydroxyheptanamide 7-[[4-(3-乙炔基苯基氨基)-7-甲氧基喹唑啉-6-基]氧基]-N-羟基庚酰胺
CAS 1012054-59-9 MFCD112054599
化学结构图
SMILES: C#Cc1cccc(Nc2ncnc3cc(OC)c(OCCCCCCC(=O)NO)cc23)c1
化学属性
| Mol. Weight | 434.49 |
|---|---|
| Mol. Formula | C24H26N4O4 |
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| CAS Number | 1012054-59-9 |
|---|---|
| Chemical Name | 7-[[4-(3-Ethynylphenylamino)-7-Methoxyquinazolin-6-Yl]Oxy]-N-Hydroxyheptanamide |
| Synonym | 7-[[4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yl]oxy]-N-hydroxyheptanamide 7-[[4-[(3-Ethynylphenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-N-hydroxyheptanamide CUDC101; CUDC 101; CUDC-101. |
| Chemical Name Translation | 7-[[4-(3-乙炔基苯基氨基)-7-甲氧基喹唑啉-6-基]氧基]-N-羟基庚酰胺 |
| Formula | C24H26N4O4 |
| IUPAC Name | 7-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide |
| InChIKey | PLIVFNIUGLLCEK-UHFFFAOYSA-N |
| InChI | InChI=1S/C24H26N4O4/c1-3-17-9-8-10-18(13-17)27-24-19-14-22(21(31-2)15-20(19)25-16-26-24)32-12-7-5-4-6-11-23(29)28-30/h1,8-10,13-16,30H,4-7,11-12H2,2H3,(H,28,29)(H,25,26,27) |
| Canonical SMILES | O=C(NO)CCCCCCOC1=CC2=C(NC3=CC=CC(C#C)=C3)N=CN=C2C=C1OC |
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分类
- Aromatics
- Heterocycles
- Inhibitors
- Pharmaceuticals
- Intermediates & Fine Chemicals
产品应用
- CUDC-101 is a multi-targeted, small-molecule inhibitor of histone deacetylase (HDAC), epidermal growth factor receptor tyrosine kinase (EGFR/ErbB1), and human epidermal growth factor receptor 2 tyrosine kinase (HER2/neu or ErbB2) with potential antineoplastic activity. HDAC/EGFR/HER2 inhibitor CUDC-101 inhibits the activity of these three enzymes but the exact mechanism of action is presently unknown. This agent may help overcome resistance to inhibition of EGFR and Her2 through a simultaneous, synergistic inhibition of EGFR, Her2, and HDAC.
相关文献及参考
- Bali, P., et al.: Clin. Cancer Res., 11, 6382 (2005),
- Wang, D., et al.: Med. Chem., 48, 6936 (2005),
- Mann, B., et al.: Oncologist., 12, 1247 (2007),
