CAS 97-18-7 MFCD00055727-6,6’-Thiobis(2,4-Dichlorophenol) 6,6’-硫代双(2,4-二氯苯酚) TAO{mole}

6,6’-Thiobis(2,4-Dichlorophenol) 6,6’-硫代双(2,4-二氯苯酚)

CAS 97-18-7 MFCD00055727

化学结构图

SMILES: Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O

化学属性

Mol. Formula	C12H6Cl4O2S
Mol. Weight	356.04
Melting Point	184.0 to 188.0 deg-C
Density	1.61
Solubility	<0.1 G/100 ML AT 23 ºC
Appearance	白色结晶性粉末。熔点185.5-186.5℃。不溶于水，易溶于乙醇、丙酮、乙醚等。

别名和识别编码

Chemical Name	6,6’-Thiobis(2,4-Dichlorophenol)
MDL Number	MFCD00055727
CAS Number	97-18-7
Synonym	Neopellis 2,2-THIOBIS(4,6-DICHLOROPHENOL) 2,2’-thiobis(4,6-dichloro-pheno 硫氯酚 2,2’-thiobis(4,6-dichlorophenol)[qr] Bitin 别丁 BITHIONOL 硫双二氯酸(别丁) 硫氯粉 2,2′-硫代双(4,6-二氯苯酚) 双(2-羟基-3,5-二氯苯)硫醚 Bis(2-hydroxy-3,5-dichlorophenyl) sulfide actamer[qr] 2,2'-Thio-bis(4,6-dichlorophenol); Bis(2-hydroxy-3,5-dichlorophenyl) sulfide ai3-50518[qr] 3,5-DICHLORO-2-HYDROXYPHENYL SULFIDE 2,2'-硫代双(4,6-二氯酚) 2,2’-dihydroxy-3,3’,5,5’-tetrachlorodiphenylsulfide[qr] XL 7 BIS(2-HYDROXY-3,5-DICHLOROPHENYL) SULFIDE 2-Hydroxy-3,5-dichlorophenyl sulfide Actamer Bithionol Lorothidol Bitionol Vancide BL 别丁/硫双二氯酚/硫氯酚 Lorothiodol 2,2'-Dihydroxy-3,3',5,5'-tetrachlorodiphenylsulfide 双(2-羟基-3,5-二氯苯)硫醚 2,2'-Dihydroxy-3,3',5,5'-tetrachlorodiphenyl sulfide 硫双二氯酚 NCI-C60628 Nobacter USAF B-22 2,2’-thiobis[4,6-dichloro-pheno 2-hydroxy-3,5-dichlorophenylsulphide TKhsd Bidiphen 2-Hydroxy-3,5-dichlorophenyl sulphide CP 3438 2,2’-dihydroxy-3,3’,5,5’-tetrachlorodiphenylsulfide 2,2'-Thiobis(4,6-dichlorophenol) 2,2'-THIOBIS(4,6-DICHLOROPHENOL) 2,2′-硫双(4,6-二氯酚) 2,2’-thiobis(4,6-dichloro)-pheno D 26 2,2’-硫代双(4,6-二氯酚) 2-hydroxy-3,5-dichlorophenylsulphide[qr] Bis(3,5-dichloro-2-hydroxyphenyl) sulfide
PubChem Substance ID	87576694
Beilstein Registry Number	2003535
EC Number	202-565-0
Reaxys-RN	2003535
Merck Number	1306
Chemical Name Translation	6,6’-硫代双(2,4-二氯苯酚)
Wiswesser Line Notation	QR BG DG FSR BQ CG EG
LabNetwork Molecule ID	LN01342345
InChI	InChI=1S/C12H6Cl4O2S/c13-5-1-7(15)11(17)9(3-5)19-10-4-6(14)2-8(16)12(10)18/h1-4,17-18H

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分类

{SNA} Additional Standards, Analytical Standards, Antibiotics A to Z, Antibiotics A-F, Antibiotics Standards, Antiparasitic / Antiprotozoal / Anthelminthic, Chemical Structure, Chromatography, Clinical Standards, Diphenylsulfides, Food and Cosmetic Component Standards, Pesticides, Bactericides, Fungicides and Disinfectants, Pharmaceuticals, Illicit Drugs & Alcohol, Spectrum of Activity, Standards for Personal Care and Cosmetic Products, neats, prohibited substances (EU-REGULATION No 1223/2009), 分析/色谱, 抗生素, 生化试剂
{Chemicalbook} 饲料添加剂: 驱虫保健剂
{SNA} Analytical Standards, Analytical/Chromatography, Antibiotics, Antibiotics A to Z,

产品应用

驱虫药。对肺吸虫囊蚴有明显杀灭作用。临床治疗肺吸虫病疗效最佳；对姜片虫、华支睾吸虫及绦虫均有效。有蛔虫和钩虫患者，应先驱蛔虫、钩虫后再服该品。

安全信息

WGK Germany3

GHS Symbol

Precautionary statements

P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P301+P310+P330
P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P501 Dispose of contents/container to..… 处理内容物/容器.....
P332+P313
P405 Store locked up. 上锁保管。
P301+P310
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P302+P350
P305+P351+P338+P337+P313
P302+P352+P332+P313+P362+P364

Hazard statements

H300 Fatal if swallowed 吞食致命

RTECSSN0525000

Signal word Danger

Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

Hazard Codes T+ Xn T+,Xn

Safety Statements

S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S36 Wear suitable protective clothing 穿戴适当的防护服；

Risk Statements

R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
R28 Very toxic if swallowed 吞咽极毒

UN Number 2811 UN 2811 6.1/PG 2

Packing GroupII

Hazard Class6.1

Storage condition 0-6°C

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 12 gm/kg/78W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Blood - tumors
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB223-159

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: AD277-689

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 760 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,612,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 7 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CLDND* Compilation of LD50 Values of New Drugs.  (J.R. MacDougal, Dept. of
   National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa,
   Ont., Canada)

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 18 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#01763

其他信息

图谱信息:硫氯酚(97-18-7)核磁图( 1 HNMR) 硫氯酚(97-18-7)核磁图( 13 CNMR) 硫氯酚(97-18-7)红外图谱(IR1) 硫氯酚(97-18-7)红外图谱(IR2) 硫氯酚(97-18-7)质谱(MS)
MOL 文件:97-18-7.mol
上游原料:三氯化铝 --> 氯 --> 三氯乙烯 --> 二氯化二硫 --> 二氯化硫 --> 2,4-二氯酚 --> 2,6-二氯苯酚 --> 2,3-二氯苯酚 --> 硫双二氯酚钠
TCI Shanghai:2,2'-硫代二(4,6-二氯苯酚) 2,2'-Thiobis(4,6-dichlorophenol),>;97.0%(GC)(T)(97-18-7)
硫氯酚价格(试剂级):更新日期产品编号产品名称包装价格 2014/06/02 T0865 2,2'-硫代二(4,6-二氯苯酚) 2,2'-Thiobis(4,6-dichlorophenol) 500G 3680元 2014/06/02 T0865 2,2'-硫代二(4,6-二氯苯酚) 2,2'-Thiobis(4,6-dichlorophenol) 25G 457元
MSDS 信息:2,2'-Thio-bis(4,6-dichlorophenol)(97-18-7).msds
白色结晶性粉末
用途二:驱虫药。对肺吸虫囊蚴有明显杀灭作用。临床治疗肺吸虫病疗效最佳；对姜片虫、华支睾吸虫及绦虫均有效。有蛔虫和钩虫患者，应先驱蛔虫、钩虫后再服该品。
用途一:作为驱虫药，对动物的绦虫和吸血虫均有驱除作用。
方法二:以苯酚为原料，先氯化生成2,4-二氯苯酚，然后再用一氯化硫进行硫化生成硫双二氯酚。（1）氯化苯酚与氯反应制得2,4-二氯苯酚：首先将苯酚熔融，在57-63℃通入干燥氯气35h。反应结束后，得到2,4-二氯苯酚。收率可达91.5%左右。（2）硫化二氯苯酚与一氯化硫在三氯乙烯和无水三氯化铝存在下，反应得硫双二氯酚：在的应罐内依次加入二氯苯酚、三氯乙烯、无水三氯化铝在50±2℃加入一氯化硫，大约2.5h加完，再恒温反应2h。过滤，用三氯乙烯洗涤、烘干，得粗硫双二氯酚。收率可达51.3%左右。（3）精制在的反应罐内加入粗硫双二氯酚，再加入氢氧化钠溶液，加热溶解后，降温至0℃，加氯化钠，搅拌使之盐析，再加饱和氯化钠溶液，搅拌均匀。静置，过滤，用饱和氯化钠溶液洗涤，回收，得到硫双二氯酚钠。再将其溶于蒸馏水中，经过滤，搅拌加入80℃左右3.5%的盐酸，析出沉淀，静置，分出上层液。沉淀用蒸馏水洗涤至pH值为2，过滤、水洗至pH为7左右，烘干得硫双二氯酚。
方法一:以苯酚为原料经氯化、硫化得硫酸二氯酚。干燥的氯气通入熔融的苯酚（57-63℃），35h后2,4-二氯酚，收率越91.5%。然后将二氯苯酚、三氯乙烯、无水三氯化铝加入反应釜，于48-52℃下通二氯化硫（SOCl2）2.5h，并恒温反应2h。冷却后过滤，用三氯乙烯洗涤，烘干得硫氯酚粗品。粗硫氯酚溶解于热氢氧化钠溶液，冷却后加食盐盐析，用饱和食盐水洗涤得硫氯酚钠。硫氯酚钠溶于水，过滤后加入稀盐酸酸析。静置后滤出沉淀，水洗至中性，烘干得成品。
Sigma Aldrich:97-18-7(sigmaaldrich)