CAS 95-80-7 MFCD00007804-2,4-Diaminotoluene 2,4-二氨基甲苯 TAO{mole}

2,4-Diaminotoluene 2,4-二氨基甲苯

CAS 95-80-7 MFCD00007804

化学结构图

SMILES: Cc1ccc(N)cc1N

化学属性

Mol. Formula	C7H10N2
Mol. Weight	122.17
Boiling Point	292°C(lit.)
Melting Point	97.0 to 100.0 deg-C
Flash Point	169°(336°F)
TSCA	Yes
Solubility	50 G/L (25 ºC)
Stability	对湿度敏感
Density	1.107

别名和识别编码

Chemical Name	2,4-Diaminotoluene
CAS Number	95-80-7
Synonym	4-Methylbenzene-1,3-diamine {LY} 4-Methylbenzene-1,3-diamine {} {LY} 4-Methylbenzene-1,3-diamine {} {} {LY} 4-Methylbenzene-1,3-diamine {} {} {} {LY} 4-Methylbenzene-1,3-diamine {} {} {} {} {LY} 4-Methylbenzene-1,3-diamine {} {} {} {} {} {LY} 4-Methylbenzene-1,3-diamine {} {} {} {} {} {} {LY} 4-Methylbenzene-1,3-diamine {} {} {} {} {} {} {} {LY} 4-Methylbenzene-1,3-diamine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Methylbenzene-1,3-diamine {} {} {} {} {} {} {} {} {} {LY} 4-Methylbenzene-1,3-diamine {} {} {} {} {} {} {} {} {} {} {LY} 4-Methylbenzene-1,3-diamine {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Methylbenzene-1,3-diamine {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Methylbenzene-1,3-diamine {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Methylbenzene-1,3-diamine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Methylbenzene-1,3-diamine {} {} {} {} {} {} {} {} {} {} {}
PubChem Substance ID	87566860
EC Number	202-453-1
Beilstein Registry Number	13,124
MDL Number	MFCD00007804
Reaxys-RN	2205839
Chemical Name Translation	2,4-二氨基甲苯
Wiswesser Line Notation	ZR CZ D1
LabNetwork Molecule ID	LN00227129
InChI	InChI=1S/C7H10N2/c1-5-2-3-6(8)4-7(5)9/h2-4H,8-9H2,1H3
Canonical SMILES	NC1=CC=C(C)C(N)=C1

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分类

{uni_hamburg} no charge; carbocycle; aromatic; 6RingOnly; 6ring; 1fragment
{SNA} 2002/61/EC, All alphabetical sorted, Alpha Sort, Alphabetical Index of Analytical Standards, Amines, Analytical Standards, Aromatics, Aryl Amines MAK III, Category 2, Chemical Class, Chromatography, Colors, Environmental Standards, European Community: ISO, DIN and DL 152, M, META - METH, Method and Regulation Specific, Oeko-Tex Standard 100, Volatiles/ Semivolatiles, 分析/色谱
{SNA} 2002/61/EC, Additional Standards, All alphabetical sorted, Alpha Sort, Amines, An

产品应用

是有机合成原料之一，可制取甲苯二异氰酸酯。也用作染料中间体、毛发染黑

安全信息

GHS Symbol

WGK Germany3

Hazard statements

H301 Toxic if swallowed 吞食有毒
H301+H311
H312 Harmful in contact with skin 皮肤接触有害
H317 May cause an allergic skin reaction 可能导致皮肤过敏
H341 Suspected of causing genetic defects 怀疑导致遗传性缺陷
H350 May cause cancer 可能致癌
H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
H411 Toxictoaquaticlifewithlonglastingeffects 对水生生物有毒性并具有长期影响。

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Hazard Codes T,N T;N

RTECSXS9625000

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
P273 Avoid release to the environment. 避免释放到环境中。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P301+P310
P301+P310+P330
P302+P350
P302+P352+P312+P361+P364
P304+P340
P304+P340+P312
P305+P351+P338
P305+P351+P338+P337+P313
P308+P311
P308+P313
P337+P313
P361 Remove/Take off immediately all contaminated clothing. 立即去除/脱掉所有被污染的衣服。
P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
P403+P233
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Signal word Danger {} {} {TCI}

UN Number 1709 UN 1709 6.1/PG 3 UN1709

Safety Statements

S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；

Risk Statements

R25 Toxic if swallowed 吞咽有毒
R21 Harmful in contact with skin 与皮肤接触有害
R48/22
R45 May cause cancer 可能致癌
R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
R62 Possible risk of impaired fertility 有削弱生殖能力的危险
R51/53
R36 Irritating to eyes 刺激眼睛

Packing GroupIII

Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

Hazard Class6.1

Warnings 危化品目录(2015)

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 9000 mg/kg/36W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   29,1137,1969

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5030 mg/kg/84W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
   Blood - lymphoma, including Hodgkin's disease
REFERENCE :
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-162,1979

TYPE OF TEST            : TD

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 16800 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
REFERENCE :
   GANNA2 Gann.  Japanese Journal of Cancer Research.  (Tokyo, Japan)  V.1-75,
   1907-84.  For publisher information, see JJCREP.  Volume(issue)/page/year:
   70,453,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2100 mg/kg/90W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
   Skin and Appendages - tumors
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(issue)/page/year: 62,1107,197

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 480 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JEPTDQ Journal of Environmental Pathology and Toxicology.  (Park Forest
   South, IL)  V.1-5(3), 1977-81(?).  For publisher information, see JEPOEC.
   Volume(issue)/page/year: 3(1-2),149,1979

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 350 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Cardiac - pulse rate
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   ZEPTAT Zeitschrift fuer Experimentelle Pathologie und Therapie.  (Berlin,
   Ger.)  V.1-22, 1905-21. For publisher information, see REXMAS.
   Volume(issue)/page/year: 17,59,1915

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Brain and Coverings - other degenerative changes
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   ZEPTAT Zeitschrift fuer Experimentelle Pathologie und Therapie.  (Berlin,
   Ger.)  V.1-22, 1905-21. For publisher information, see REXMAS.
   Volume(issue)/page/year: 17,59,1915

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   XPHBAO U.S. Public Health Service, Public Health Bulletin.  (Washington

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 15200 mmol/L/3D
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 48,181,1977

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 2 gm/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 135,115,1984

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 10 ug/plate
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(issue)/page/year: 76,291,1986

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Human Fibroblast
DOSE/DURATION           : 100 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 127,107,1984

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 300 mg/kg
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 12,2233,1991

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 4 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1260 mg/kg
SEX/DURATION            : male 10 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
   Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
   accessory glands
REFERENCE :
   JTEHD6 Journal of Toxicology and Environmental Health.  (Hemisphere Pub.,
   1025 Vermont Ave., NW, Washington, DC 20005)  V.1-    1975/76-
   Volume(issue)/page/year: 16,763,1985

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1260 mg/kg
SEX/DURATION            : male 10 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - mating performance (e.g. # sperm positive females
   per # females mated; # copulations per # estrus cycles)
REFERENCE :
   JTEHD6 Journal of Toxicology and Environmental Health.  (Hemisphere Pub.,
   1025 Vermont Ave., NW, Washington, DC 20005)  V.1-    1975/76-
   Volume(issue)/page/year: 16,753,1985

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 1200 mg/kg
SEX/DURATION            : female 6-13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
   Reproductive - Effects on Newborn - live birth index (measured after birth)
REFERENCE :
   TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis.  (Alan R. Liss, Inc.,
   41 E. 11th St., New York, NY 10003)  V.1-    1980- Volume(issue)/page/year:
   7,29,1987

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE

Restrict 危险品

其他信息

刺激数据:皮肤- 兔子 500 毫克/ 24小时轻度; 眼- 兔子 100 毫克/ 24小时中度
外观性质:无色针状或菱形结晶。
Acros Organics:1-甲基-2，4-苯二胺 2,4-Diaminotoluene, 98%(95-80-7)
储运特性:库房通风低温干燥; 与氧化剂、食品添加剂、酸类分开存放
急性毒性:腹抢- 大鼠 LD50: 325 毫克/ 公斤; 腹腔- 小鼠 LD50: 480 毫克/ 公斤
图谱信息:2,4-二氨基甲苯(95-80-7)红外图谱(IR2) 2,4-二氨基甲苯(95-80-7)核磁图( 13 CNMR) 2,4-二氨基甲苯(95-80-7)质谱(MS) 2,4-二氨基甲苯(95-80-7)核磁图( 1 HNMR) 2,4-二氨基甲苯(95-80-7)红外图谱(IR1)
类别:有毒物品
溶于水、乙醇、乙醚。
MSDS 信息:2,4-二氨基甲苯(95-80-7).msds
色指数:76035
海关编码:29331990
用途一:用于制取TDI、硫化染料、碱性染料、分散染料、医药中间体及其他有机合成的中间体
用途二:有机合成中间体。用于生产甲苯二异氰酸酯，染料毛皮黑DB、硫化黄棕5G、硫化黄棕6G、硫化红棕B3R等。制成的染料可使皮毛、头发直接氧化成黑色。
MOL 文件:95-80-7.mol
灭火剂:泡沫、雾状水、二氧化碳、砂土
方法一:由对硝基甲苯用混酸硝化得2,4-二硝基甲苯，然后用铁粉还原得粗品，再经浓缩、蒸馏得成品。原料消耗定额：对硝基甲苯1600kg/t、硫酸（98%）1616kg/t、硝酸（98%）760kg/t、铁粉（90%）2700kg/t。
2,4-二氨基甲苯价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 80043125 2，4-二氨基甲苯;2,4-甲苯二胺;2,4-叨二胺; 4-甲基间苯二胺 50g 23元 2011/08/23 80043126 2，4-二氨基甲苯;2,4-甲苯二胺;2,4-叨二胺; 4-甲基间苯二胺 100g 45.6元 2011/04/16 D0123 2,4-二氨基甲苯 2,4-Diaminotoluene 25G 175元
TCI Shanghai:2,4-二氨基甲苯 2,4-Diaminotoluene,>;98.0%(GC)(T)(95-80-7)
F:8-10-23
Alfa Aesar:2,4-二氨基甲苯,98% 2,4-Diaminotoluene, 98%(95-80-7)
下游产品:2,4-二氯甲苯 --> 2,4-二氯苯甲酸 --> 1,4-二氨基蒽醌 --> 1,4-二氨基蒽醌隐色体 --> 硫化黄GC --> 硫化褐 10号 --> 硫化红棕B3R --> 硫化红6 --> 硫化黄棕6G --> 硫化黄2 --> 2,4-二溴苯甲酸
毒性分级:高毒
用途三:是有机合成原料之一，可制取甲苯二异氰酸酯。也用作染料中间体、毛发染黑
可燃性危险特性:明火可燃;高热分解有毒氮氧化物烟雾
上游原料:硫酸 --> 4-硝基甲苯 --> 2,4-二硝基甲苯
Sigma Aldrich:95-80-7(sigmaaldrich)