CAS 94-63-3 MFCD00011982-Pyridine-2-Aldoxime Methiodide 吡啶-2-乙醛肟甲碘化物 TAO{mole}

Pyridine-2-Aldoxime Methiodide 吡啶-2-乙醛肟甲碘化物

CAS 94-63-3 MFCD00011982

化学结构图

SMILES: C[n+]1ccccc1C=NO.[I-]

化学属性

Mol. Formula	C7H11IN2O
Mol. Weight	266.08
Melting Point	220 °C (dec.)(lit.)
TSCA	No
Appearance	淡黄色针状结晶性粉末。熔点225-226℃。25℃水中溶解度为48mg/ml。碱性溶液中易破坏。

别名和识别编码

Chemical Name	Pyridine-2-Aldoxime Methiodide
CAS Number	94-63-3
MDL Number	MFCD00011982
EC Number	202-349-6
Synonym	2-Formyl-1-methylpyridinium iodide oxime 碘解磷啶 2-pyridinealdoximeiodomethylate Pralidoxime methiodide Pyridin-2-aldoxin 2-pyridinaldoximmethojodid 2-PYRIDINEALDOXIME METHIODIDE PYRIDINE-2-CARBOXALDOXIME METHIODIDE Pyridine-2-aldoxime methiodide LABOTEST-BB LT00455561 2-Hydroxyiminomethyl-1-methylpyridinium iodide PRALIDOXIME IODIDE Pyridine-2-aldoxime methyl iodide 2-PAM 碘化物 2-FORMYL-1-METHYLPYRIDINIUM IODIDE OXIME PAM 磷敌 2-Formyl-N-methylpyridinium oxime iodide Pralidoxime iodide 吡啶-2-甲醛肟碘甲烷盐 p-2-am 解磷定 1-methyl-2-hydroxyiminomethylpyridiniumiodide 碘解磷定 2-pamiodide 碘解磷 n-methylpyridinium-2-aldoximeiodide 2-Pyridine aldoxime iodomethylate 2-PAM iodide 1-methyl-2-aldoximinopyridiniumiodide 吡啶-2-乙醛肟甲碘化物 2-PAM
PubChem Substance ID	135410029
Beilstein Registry Number	4163555
Chemical Name Translation	吡啶-2-乙醛肟甲碘化物
Merck Number	13,7788
Wiswesser Line Notation	T6KJ A1 B1UNQ &Q &I
InChI	InChI=1S/C7H8N2O.HI/c1-9-5-3-2-4-7(9)6-8-10;/h2-6H,1H3;1H

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安全信息

Hazard Codes Xn

Safety Statements

S36 Wear suitable protective clothing 穿戴适当的防护服；

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R22 Harmful if swallowed 吞咽有害

WGK Germany3

GHS Symbol

Hazard statements

H302 Harmful if swallowed 吞食有害

RTECSUU4375000

Signal word

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves

Storage condition Light Sensitive

Precautionary statements

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 145 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 132,50,1961

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 305 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 13,202,1958

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 140 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AEHLAU Archives of Environmental Health.  (Heldref Pub., 4000 Albemarle St.,
   NW, Washington, DC 20016)  V.1-    1960-  Volume(issue)/page/year: 5,21

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 178 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 129,31,1960

其他信息

用途一:用于烷基磷酸酯类家药中毒的解毒剂。该品是胆碱酯酶再激活剂。
Alfa Aesar:Pyridine-2-aldoxime methiodide, 99%(94-63-3)
MOL 文件:94-63-3.mol
上游原料:碘化钾 --> 2-甲基吡啶 --> 2-吡啶醛肟甲氯 --> 碘化钾饱和溶液
方法一:由氯解磷定置换得到。将氯解磷定加等量水，加热溶解，搅拌下滴加碘化钾饱和溶液，析出结晶，过滤，甩干。再用蒸馏水重结晶，活性炭脱色得碘解磷定。
Sigma Aldrich:94-63-3(sigmaaldrich)